| UniProt/SwissProt ID: | E2AK4_HUMAN |
| Description: | eukaryotic translation initiation factor 2 alpha kinase 4 [Source:HGNC Symbol;Acc:19687] |
| Location: | chr15 q15.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T1085 | AVQLCtPLLLP | tRNA-synt_2b | PhosphoSitePlus |
| Y253 | RRERQySVCNS | Pkinase | PhosphoSitePlus |
| T667 | PAGPGtPPPDS | Pkinase | PhosphoSitePlus; SysPTM |
| S572 | SNRLPsAAFFS | Pkinase | PhosphoSitePlus |
| T991 | PAKRPtATELL | tRNA-synt_2b | PhosphoSitePlus |
| S551 | PLVEQsPEDSE | Pkinase | PhosphoSitePlus |
| S230 | ILHGGsPDFVG | HPRD; phosphoELM; SysPTM | |
| S555 | QSPEDsEGQDY | Pkinase | PhosphoSitePlus |
| S254 | RERQYsVCNSE | Pkinase | PhosphoSitePlus |
| Y560 | SEGQDyVETVI | Pkinase | PhosphoSitePlus |
| T667 | PAGPGtPPPDS | HPRD; phosphoELM; SysPTM | |
| S205 | RLEIAsLSNQD | HPRD | |
| S1040 | FSQRIsPAIDY | HPRD | |
| Y269 | SCEILyFNMGS | Pkinase | PhosphoSitePlus |
| S928 | KVDLFsLGIIF | PhosphoSitePlus | |
| S230 | ILHGGsPDFVG | Pkinase | PhosphoSitePlus; SysPTM |
| Y500 | QECGEyPVTIP | Pkinase | PhosphoSitePlus |
| S261 | CNSEDsPGSCE | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| E2AK4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000263791 | E460Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000372174 | E460Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000263791 | E54K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000263791 | H939Y | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 | ENSP00000372174 | E54K | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| E2AK4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| E2AK4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| E2AK4_HUMAN | IF2A_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05169 | Epstein-Barr virus infection |
| hsa05160 | Hepatitis C |
| hsa04141 | Protein processing in endoplasmic reticulum |
| hsa05164 | Influenza A |
| hsa05162 | Measles |
| hsa05168 | Herpes simplex infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004674 | protein serine/threonine kinase activity | ISS | molecular_function |
| GO:0006468 | protein phosphorylation | ISS | biological_process |
| GO:0000049 | tRNA binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0042803 | protein homodimerization activity | IEA | molecular_function |
| GO:0006446 | regulation of translational initiation | ISS | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0009267 | cellular response to starvation | IEA | biological_process |
| GO:0004694 | eukaryotic translation initiation factor 2alpha ki | ISS | molecular_function |
| GO:0043558 | regulation of translational initiation in response | IEA | biological_process |
| GO:0030968 | endoplasmic reticulum unfolded protein response | IEA | biological_process |
| GO:0017148 | negative regulation of translation | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005622 | intracellular | NAS | cellular_component |
| GO:0022626 | cytosolic ribosome | ISS | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |