Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:E2AK4_HUMAN
Description:eukaryotic translation initiation factor 2 alpha kinase 4 [Source:HGNC Symbol;Acc:19687]
Location:chr15 q15.1
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1085AVQLCtPLLLPtRNA-synt_2bPhosphoSitePlus
Y253RRERQySVCNSPkinasePhosphoSitePlus
T667PAGPGtPPPDSPkinasePhosphoSitePlus; SysPTM
S572SNRLPsAAFFSPkinasePhosphoSitePlus
T991PAKRPtATELLtRNA-synt_2bPhosphoSitePlus
S551PLVEQsPEDSEPkinasePhosphoSitePlus
S230ILHGGsPDFVGHPRD; phosphoELM; SysPTM
S555QSPEDsEGQDYPkinasePhosphoSitePlus
S254RERQYsVCNSEPkinasePhosphoSitePlus
Y560SEGQDyVETVIPkinasePhosphoSitePlus
T667PAGPGtPPPDSHPRD; phosphoELM; SysPTM
S205RLEIAsLSNQDHPRD
S1040FSQRIsPAIDYHPRD
Y269SCEILyFNMGSPkinasePhosphoSitePlus
S928KVDLFsLGIIFPhosphoSitePlus
S230ILHGGsPDFVGPkinasePhosphoSitePlus; SysPTM
Y500QECGEyPVTIPPkinasePhosphoSitePlus
S261CNSEDsPGSCEPkinasePhosphoSitePlus

Dephosphorylation site
E2AK4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263791E460QBIOMARTBreast Cancer21930507, 21930502
ENSP00000372174E460QBIOMARTBreast Cancer21930507, 21930502
ENSP00000263791E54KBIOMARTBreast Cancer21930507, 21930502
ENSP00000263791H939YGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000372174E54KBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
E2AK4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
E2AK4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
E2AK4_HUMANIF2A_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05169Epstein-Barr virus infection
hsa05160Hepatitis C
hsa04141Protein processing in endoplasmic reticulum
hsa05164Influenza A
hsa05162Measles
hsa05168Herpes simplex infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004674protein serine/threonine kinase activityISSmolecular_function
GO:0006468protein phosphorylationISSbiological_process
GO:0000049tRNA bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0006446regulation of translational initiationISSbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0009267cellular response to starvationIEAbiological_process
GO:0004694eukaryotic translation initiation factor 2alpha kiISSmolecular_function
GO:0043558regulation of translational initiation in responseIEAbiological_process
GO:0030968endoplasmic reticulum unfolded protein responseIEAbiological_process
GO:0017148negative regulation of translationIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005622intracellularNAScellular_component
GO:0022626cytosolic ribosomeISScellular_component
GO:0005524ATP bindingIEAmolecular_function


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