Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DYN2_HUMAN
Description:dynamin 2 [Source:HGNC Symbol;Acc:2974]
Location:chr19 p13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S758LQSASsHSPTPHPRD
T280PHLQKtLNQQLDynamin_MPhosphoSitePlus
S581EKGFMsNKHVFPHPhosphoSitePlus
T755PPVDDtWLQSAHPRD
T591FAIFNtEQRNVPH; KcnmB2_inactivPhosphoSitePlus
S662RNLVDsYVAIIHPRD
Y563EKEKKyMLPLDHPRD
T527RRGWLtINNISPHPhosphoSitePlus
T751PPVDDtWLQSAHPRD
S755DTWLQsASSHSHPRD
Y597EQRNVyKDLRQPH; KcnmB2_inactivPhosphoSitePlus
T766SSHSPtPQRRPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T587FAIFNtEQRNVHPRD
S757WLQSAsSHSPTHPRD
S848PPGVPsRRPPAPhosphoSitePlus
T200PQGLRtIGVITHPRD
S762LQSASsHSPTPHPRD; phosphoELM
S577EKGFMsNKHVFHPRD
Y563EKEKKyMLPLDPHPhosphoSitePlus
Y449SKLSSyPRLREHPRD; SysPTM
S528TINNIsLMKGGHPRD
S532TINNIsLMKGGPHPhosphoSitePlus
Y231PLRRGyIGVVNDynamin_MPhosphoSitePlus
T286LNQQLtNHIREDynamin_MPhosphoSitePlus
S759DTWLQsASSHSPhosphoSitePlus; HPRD
S662RNLVDsYVAIIGEDPhosphoSitePlus
Y449SKLSSyPRLREDynamin_MPhosphoSitePlus; SysPTM
S761WLQSAsSHSPTPhosphoSitePlus; HPRD; phosphoELM
S764SASSHsPTPQRPhosphoSitePlus; HPRD; phosphoELM
S615DSWKAsFLRAGHPRD
Y663NLVDSyVAIINGEDPhosphoSitePlus
T591FAIFNtEQRNVHPRD
S658RNLVDsYVAIIHPRD
Y726DMLRMyHALKEGEDPhosphoSitePlus
S581EKGFMsNKHVFHPRD
S619DSWKAsFLRAGHPRD
Y125INLRVySPHVLDynamin_NPhosphoSitePlus
Y559EKEKKyMLPLDHPRD
T762SSHSPtPQRRPHPRD
S532TINNIsLMKGGHPRD
S760SASSHsPTPQRHPRD
S116K.GISPVPINLR.VSysPTM 2.0

Dephosphorylation site
DYN2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000352721R318WTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000352721acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000352721acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343

Hyperphosphorylation site
DYN2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KC1E_HUMANDYN2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
DYN2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0014069postsynaptic densityIEAcellular_component
GO:0019899enzyme bindingNASmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0030054cell junctionIEAcellular_component
GO:0003924GTPase activityIEAmolecular_function
GO:0031623receptor internalizationIMPbiological_process
GO:0033572transferrin transportIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008017microtubule bindingNASmolecular_function
GO:0006892post-Golgi vesicle-mediated transportTASbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0016044cellular membrane organizationTASbiological_process
GO:0005737cytoplasmNAScellular_component
GO:0019886antigen processing and presentation of exogenous pTASbiological_process
GO:0048489synaptic vesicle transportNASbiological_process
GO:0045211postsynaptic membraneIDAcellular_component
GO:0007165signal transductionNASbiological_process
GO:0000139Golgi membraneTAScellular_component
GO:0005525GTP bindingIEAmolecular_function
GO:0006184GTP catabolic processNASbiological_process
GO:0005874microtubuleIDAcellular_component
GO:0030496midbodyIEAcellular_component
GO:0006355regulation of transcription, DNA-dependentNASbiological_process
GO:0006897endocytosisNASbiological_process
GO:0000086G2/M transition of mitotic cell cycleNASbiological_process
GO:0043065positive regulation of apoptotic processNASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process


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