| UniProt/SwissProt ID: | DUFFY_HUMAN |
| Description: | Duffy blood group, chemokine receptor [Source:HGNC Symbol;Acc:4035] |
| Location: | chr1 q23.2 |
| Node attribute: | receptor |
| Phosphorylation site |
| DUFFY_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| DUFFY_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000357104 | L265Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000357104 | F81V | COSMIC | Lung Cancer | ENSP00000352341 | N44D | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000357104 | S152F | COSMIC | Skin Cancer | 21984974 | ENSP00000357104 | H256N | BIOMART | Gastric Cancer | 21930507, 21930502 |
| Differential expressed protein |
| DUFFY_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DUFFY_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GROA_HUMAN | DUFFY_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05144 | Malaria |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0004950 | chemokine receptor activity | NAS | molecular_function |
| GO:0006954 | inflammatory response | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0006952 | defense response | NAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0019957 | C-C chemokine binding | IPI | molecular_function |
| GO:0032642 | regulation of chemokine production | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0070098 | chemokine-mediated signaling pathway | NAS | biological_process |
| GO:0004872 | receptor activity | TAS | molecular_function |