| UniProt/SwissProt ID: | DOK2_HUMAN |
| Description: | docking protein 2, 56kDa [Source:HGNC Symbol;Acc:2991] |
| Location: | chr8 p21.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y345 | RPDHIyDEPEG | SRC | HPRD |
| T189 | GPEPGtQLYDW | IRS | PhosphoSitePlus |
| Y402 | QPGTEyDNVVL | PhosphoSitePlus | |
| S332 | DPLYDsIEETL | PhosphoSitePlus | |
| Y12 | KQGFLyLQQQQ | PH | PhosphoSitePlus |
| S309 | DAVARsLGKNF | PhosphoSitePlus | |
| Y357 | AALSLyDSPQE | PhosphoSitePlus | |
| Y299 | GQEGEyAVPFD | SRC | HPRD; SysPTM |
| Y299 | GQEGEyAVPFD | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S269 | LPRPDsPYSRP | PhosphoSitePlus | |
| S277 | SRPHDsLPPPS | PhosphoSitePlus | |
| S122 | QRKELsGPEGK | PhosphoSitePlus | |
| Y299 | GQEGEyAVPFD | LYN | HPRD; SysPTM |
| Y345 | RPDHIyDEPEG | HCK | HPRD |
| S140 | ENELYsSAVTV | PhosphoSitePlus | |
| Y170 | HLRGSyTLRAG | IRS | PhosphoSitePlus |
| Y271 | RPDSPySRPHD | LYN | HPRD |
| Y345 | RPDHIyDEPEG | PhosphoSitePlus; HPRD; phosphoELM | |
| S141 | NELYSsAVTVG | PhosphoSitePlus | |
| Y345 | RPDHIyDEPEG | LYN | HPRD |
| Y271 | RPDSPySRPHD | PhosphoSitePlus; HPRD; phosphoELM | |
| Y139 | EENELySSAVT | PhosphoSitePlus; HPRD; phosphoELM | |
| Y271 | RPDSPySRPHD | SRC | HPRD |
| S129 | PEGKQsRPCME | PhosphoSitePlus | |
| Y271 | RPDSPySRPHD | HCK | HPRD |
| T144 | YSSAVtVGPHK | PhosphoSitePlus | |
| Y330 | LADPLyDSIEE | PhosphoSitePlus | |
| Y192 | PGTQLyDWPYR | IRS | PhosphoSitePlus |
| S282 | SLPPPsPTTPV | PhosphoSitePlus | |
| T336 | DSIEEtLPPRP | PhosphoSitePlus | |
| Y299 | GQEGEyAVPFD | HCK | HPRD; SysPTM |
| Dephosphorylation site |
| DOK2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000276420 | V384F | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| DOK2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DOK2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| HCK_HUMAN | DOK2_HUMAN | kinase -> substrate | HPRD |
| SRC_HUMAN | DOK2_HUMAN | kinase -> substrate | HPRD |
| LYN_HUMAN | DOK2_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| DOK2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0005057 | receptor signaling protein activity | IEA | molecular_function |
| GO:0007265 | Ras protein signal transduction | IEA | biological_process |
| GO:0007169 | transmembrane receptor protein tyrosine kinase sig | IEA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005068 | transmembrane receptor protein tyrosine kinase ada | IEA | molecular_function |
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005158 | insulin receptor binding | IEA | molecular_function |
| GO:0050900 | leukocyte migration | TAS | biological_process |