Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DNM3A_HUMAN
Description:DNA (cytosine-5-)-methyltransferase 3 alpha [Source:HGNC Symbol;Acc:2978]
Location:chr2 p23.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S243KVEEAsPPAVQPhosphoSitePlus; HPRD
S102QPEEGsPAGGQphosphoELM
T261PTVATtPEPVGPhosphoSitePlus; HPRD
S255PTDPAsPTVATPhosphoSitePlus; HPRD
S178GLGWEsSLRQRPhosphoSitePlus
T138ENGCCtPKEGRPhosphoSitePlus
S75AVISKsPSMAQHPRD
S267PEPVGsDAGDKPhosphoSitePlus
T156KEQKEtNIESMPhosphoSitePlus
S105QPEEGsPAGGQPhosphoSitePlus; HPRD
S179LGWESsLRQRPPhosphoSitePlus
S236QGPGEsQKVEEPhosphoSitePlus
S377VLQVAsSRAGKPhosphoSitePlus

Dephosphorylation site
DNM3A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000324375R729QCOSMICLymphoma21067377
ENSP00000324375V716FCOSMICLymphoma21836609
ENSP00000324375R771QCOSMICLymphoma22077061
ENSP00000324375A910TCOSMICOvarian Cancer21720365
ENSP00000324375A741VCOSMICLymphoma21067377
ENSP00000324375R736HCOSMICLymphoma22077061
ENSP00000264709Y874CCOSMICLymphoma21518476
ENSP00000324375S714CCOSMICLymphoma21415852
ENSP00000264709E477*COSMICLymphoma21537334
ENSP00000264709P904LCOSMICLymphoma21415852
ENSP00000324375F414SCOSMICOvarian Cancer21720365
ENSP00000324375W753GCOSMICLymphoma21993668
ENSP00000264709N797YCOSMICLymphoma22077061
ENSP00000264709S837*COSMICLymphoma22077061
ENSP00000324375E599*COSMICLymphoma21880636
ENSP00000264709G543CCOSMICLymphoma21909114
ENSP00000264709E30ACOSMICLymphoma21067377
ENSP00000324375K468RCOSMICLymphoma21067377
ENSP00000264709L737FCOSMICOvarian Cancer21720365
ENSP00000324375L737FCOSMICOvarian Cancer21720365
ENSP00000264709W893SCOSMICLymphoma22081665
ENSP00000264709P718LCOSMICLymphoma21067377
ENSP00000384237G476SBIOMARTMyeloproliferative Disorders21930507, 21930502
ENSP00000324375C524*COSMICLymphoma22077061
ENSP00000264709R882CCOSMICLymphoma21904384
ENSP00000324375I655NCOSMICLymphoma21993668
ENSP00000264709E599*COSMICLymphoma21880636
ENSP00000324375L889PCOSMICLymphoma21993668
ENSP00000264709M880VCOSMICLymphoma21859430
ENSP00000324375N797YCOSMICLymphoma22077061
ENSP00000264709Q237*COSMICLymphoma21415852
ENSP00000324375R882CCOSMICLymphoma21904384
ENSP00000264709A218PCOSMICLung Cancer20668451
ENSP00000324375G543CCOSMICLymphoma21909114
ENSP00000264709P431SCOSMICSkin Cancer21984974
ENSP00000324375P904LCOSMICLymphoma21415852
ENSP00000264709V636MCOSMICLymphoma21993668
ENSP00000324375R484WCOSMICLymphoma21836609
ENSP00000264709F414SCOSMICOvarian Cancer21720365
ENSP00000324375F731LCOSMICLymphoma22077061
ENSP00000264709Y735CCOSMICLymphoma21993668
ENSP00000324375I705FCOSMICLymphoma22077061
ENSP00000264709R598*COSMICLymphoma22077061
ENSP00000324375W297*COSMICLymphoma22077061
ENSP00000264709K841QCOSMICLymphoma21067377
ENSP00000324375S837*COSMICLymphoma22077061
ENSP00000324375R792HCOSMICLymphoma21067377
ENSP00000264709R635WCOSMICLymphoma21904384
ENSP00000324375Q606*COSMICLymphoma22077061
ENSP00000324375Q515*COSMICLymphoma21067377
ENSP00000324375F909CCOSMICLymphoma21067377
ENSP00000264709C524*COSMICLymphoma22077061
ENSP00000324375R635WCOSMICLymphoma21904384
ENSP00000324375W314*COSMICLymphoma22077061
ENSP00000264709I705FCOSMICLymphoma22077061
ENSP00000324375G728RCOSMICLymphoma22077061
ENSP00000324375E505*COSMICLymphoma21067377
ENSP00000324375P849RCOSMICLymphoma21993668
ENSP00000264709R478WCOSMICLymphoma21399634
ENSP00000264709G728RCOSMICLymphoma22077061
ENSP00000324375R598*COSMICLymphoma22077061
ENSP00000324375K829RCOSMICLymphoma21067377
ENSP00000324375F751fs*28COSMICLymphoma21995386
ENSP00000264709S770WCOSMICLymphoma21415852
ENSP00000324375Y874CCOSMICLymphoma21518476
ENSP00000264709K468RCOSMICLymphoma21067377
ENSP00000324375R38HCOSMICLung Cancer20668451
ENSP00000264709R803SCOSMICLymphoma21067377
ENSP00000264709W795CCOSMICLymphoma21993668
ENSP00000264709A910TCOSMICOvarian Cancer21720365
ENSP00000264709R771QCOSMICLymphoma22077061
ENSP00000324375S105RCOSMICLymphoma22077061
ENSP00000324375R803SCOSMICLymphoma21067377
ENSP00000264709E667ACOSMICHead and Neck Cancer21798893
ENSP00000264709V897DCOSMICLymphoma21399634
ENSP00000264709F731LCOSMICLymphoma22077061
ENSP00000324375Y735CCOSMICLymphoma21993668
ENSP00000324375P718LCOSMICLymphoma21067377
ENSP00000264709A741VCOSMICLymphoma21067377
ENSP00000264709I655NCOSMICLymphoma21993668
ENSP00000324375F752LCOSMICLymphoma21993668
ENSP00000264709F752LCOSMICLymphoma21993668
ENSP00000324375G699SCOSMICLymphoma21995386
ENSP00000324375A368DCOSMICLymphoma21067377
ENSP00000264709S714CCOSMICLymphoma21415852
ENSP00000324375E667ACOSMICHead and Neck Cancer21798893
ENSP00000264709R792HCOSMICLymphoma21067377
ENSP00000324375A218PCOSMICLung Cancer20668451
ENSP00000324375V897DCOSMICLymphoma21399634
ENSP00000264709R729QCOSMICLymphoma21067377
ENSP00000264709F909CCOSMICLymphoma21067377
ENSP00000324375Q237*COSMICLymphoma21415852
ENSP00000264709P896LCOSMICLung Cancer20668451
ENSP00000264709K829RCOSMICLymphoma21067377
ENSP00000324375S352NCOSMICLymphoma21993668
ENSP00000264709F751fs*28COSMICLymphoma21995386
ENSP00000264709G699SCOSMICLymphoma21995386
ENSP00000324375P896LCOSMICLung Cancer20668451
ENSP00000264709A368DCOSMICLymphoma21067377
ENSP00000324375S770WCOSMICLymphoma21415852
ENSP00000264709S352NCOSMICLymphoma21993668
ENSP00000264709V716FCOSMICLymphoma21836609
ENSP00000264709L754RCOSMICLymphoma21993668
ENSP00000264709R38HCOSMICLung Cancer20668451
ENSP00000324375W795CCOSMICLymphoma21993668
ENSP00000324375E477*COSMICLymphoma21537334
ENSP00000264709E505*COSMICLymphoma21067377
ENSP00000264709W581CCOSMICLymphoma21993668
ENSP00000324375K841QCOSMICLymphoma21067377
ENSP00000264709L889PCOSMICLymphoma21993668
ENSP00000324375Q615*COSMICLymphoma21067377
ENSP00000264709Q606*COSMICLymphoma22077061
ENSP00000264709Q615*COSMICLymphoma21067377
ENSP00000324375L754RCOSMICLymphoma21993668
ENSP00000324375E30ACOSMICLymphoma21067377
ENSP00000324375W581CCOSMICLymphoma21993668
ENSP00000264709Q678*COSMICLymphoma22077061
ENSP00000264709K721RCOSMICHead and Neck Cancer21798893
ENSP00000264709P849RCOSMICLymphoma21993668
ENSP00000264709E523*COSMICLymphoma21537334
ENSP00000324375Q816*COSMICLymphoma21828135
ENSP00000324375V636MCOSMICLymphoma21993668
ENSP00000324375R478WCOSMICLymphoma21399634
ENSP00000264709R484WCOSMICLymphoma21836609
ENSP00000264709R736HCOSMICLymphoma22077061
ENSP00000264709Q515*COSMICLymphoma21067377
ENSP00000264709S105RCOSMICLymphoma22077061
ENSP00000324375Q678*COSMICLymphoma22077061
ENSP00000324375M880VCOSMICLymphoma21859430
ENSP00000324375P431SCOSMICSkin Cancer21984974
ENSP00000324375K721RCOSMICHead and Neck Cancer21798893
ENSP00000264709L805*COSMICLymphoma21067377
ENSP00000264709W314*COSMICLymphoma22077061
ENSP00000324375E523*COSMICLymphoma21537334
ENSP00000324375R320*COSMICLymphoma22077061
ENSP00000264709W753GCOSMICLymphoma21993668
ENSP00000324375L805*COSMICLymphoma21067377
ENSP00000264709Q816*COSMICLymphoma21828135
ENSP00000264709W297*COSMICLymphoma22077061
ENSP00000264709R320*COSMICLymphoma22077061
ENSP00000324375W893SCOSMICLymphoma22081665

Differential expressed protein
DNM3A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DNM3A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DYRK2_HUMANDNM3A_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANDNM3A_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANDNM3A_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
DNM3A_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006349regulation of gene expression by genetic imprintinIEAbiological_process
GO:0044027hypermethylation of CpG islandIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0007283spermatogenesisIEAbiological_process
GO:0000775chromosome, centromeric regionIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0003886DNA (cytosine-5-)-methyltransferase activityIEAmolecular_function
GO:0006349regulation of gene expression by genetic imprintinTASbiological_process
GO:0010424DNA methylation on cytosine within a CG sequenceIEAbiological_process
GO:0000791euchromatinIDAcellular_component
GO:0003886DNA (cytosine-5-)-methyltransferase activityIDAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0008168methyltransferase activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0000792heterochromatinIEAcellular_component
GO:0045322unmethylated CpG bindingIEAmolecular_function
GO:0006306DNA methylationIDAbiological_process
GO:0046499S-adenosylmethioninamine metabolic processIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0046498S-adenosylhomocysteine metabolic processIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005720nuclear heterochromatinIEAcellular_component
GO:0006306DNA methylationIEAbiological_process
GO:0016363nuclear matrixIDAcellular_component
GO:0051718DNA (cytosine-5-)-methyltransferase activity, actiIEAmolecular_function
GO:0043045DNA methylation involved in embryo developmentIEAbiological_process
GO:0071230cellular response to amino acid stimulusIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0090116C-5 methylation of cytosineIDAbiological_process
GO:0043046DNA methylation involved in gamete generationIEAbiological_process
GO:0006346methylation-dependent chromatin silencingIEAbiological_process
GO:0005634nucleusIDAcellular_component