Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DGKZ_HUMAN
Description:diacylglycerol kinase, zeta [Source:HGNC Symbol;Acc:2857]
Location:chr11 p11.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y183WGLHGyYRRLSPhosphoSitePlus
Y529EALEMyRKVHNDAGK_catPhosphoSitePlus
S282KKKRAsFKRKSPRKCAHPRD
S163YLRRAsSHLLPPhosphoSitePlus
S205GGRRAsGTTAGPhosphoSitePlus
S514FLMGSsKDLAKHPRD
Y1105ENRQHyQMIQRPhosphoSitePlus
T207RRASGtTAGTMPhosphoSitePlus
T961TSPLPtSPCSPPhosphoSitePlus
S37KARRRsPAGQAPhosphoSitePlus
S447NTLKAsKKKKRPhosphoSitePlus
S454KKKRAsFKRKSPKCaRegPhos
S76SRRRSsTVPPSPhosphoSitePlus
T443RRPQNtLKASKPhosphoSitePlus
S1024AVSTGsKDVVRAnk_2PhosphoSitePlus
S164LRRASsHLLPAPhosphoSitePlus
S962SPLPTsPCSPTPhosphoSitePlus
S686FLMGSsKDLAKRegPhos; SysPTM
Y173PADAVyDHALWPhosphoSitePlus
S894GAGAKsPTCQKPhosphoSitePlus
S53QRRRSsAQLQGPhosphoSitePlus
S970SPTPRsLQGDAPhosphoSitePlus
Y845VSMHDyEALHYPhosphoSitePlus
S43PAGQAsSSLAQPhosphoSitePlus
S193SQRRPsGQHPGPhosphoSitePlus
S75SSRRRsSTVPPPhosphoSitePlus
S965PTSPCsPTPRSPhosphoSitePlus
T77RRRSStVPPSCPhosphoSitePlus
S24GQQRPsSVGLPPhosphoSitePlus
S1012HRDEQsRTLLHAnk_2PhosphoSitePlus
S266KKKRAsFKRKSPRKCAHPRD
S498FLMGSsKDLAKHPRD
Y508QSFLWyLNPRQDAGK_catPhosphoSitePlus
S52AQRRRsSAQLQPhosphoSitePlus
Y673RNKMFyAGTAFDAGK_accPhosphoSitePlus
S45GQASSsLAQRRPhosphoSitePlus
S957LPTPTsPLPTSPhosphoSitePlus
T215GTMLPtRVRPLPhosphoSitePlus
S266PGAPCsESERQPKCaRegPhos
T211GTTAGtMLPTRPhosphoSitePlus

Dephosphorylation site
DGKZ_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000343065E896KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000412178E857KTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000343065V871MCOSMICMelanoma

Differential expressed protein
DGKZ_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DGKZ_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANDGKZ_HUMANkinase -> substrateRegPhos
KPCA_HUMANDGKZ_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
hsa00564Glycerophospholipid metabolism
hsa00561Glycerolipid metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0030168platelet activationTASbiological_process
GO:0007205protein kinase C-activating G-protein coupled receIEAbiological_process
GO:0046834lipid phosphorylationIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0035556intracellular signal transductionIEAbiological_process
GO:0030027lamellipodiumIDAcellular_component
GO:0045930negative regulation of mitotic cell cycleIGIbiological_process
GO:0001727lipid kinase activityIDAmolecular_function
GO:0008022protein C-terminus bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIDAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0016477cell migrationNASbiological_process
GO:0031571mitotic cell cycle G1/S transition DNA damage checIGIbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0004143diacylglycerol kinase activityIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0043086negative regulation of catalytic activityIEAbiological_process
GO:0004857enzyme inhibitor activityIEAmolecular_function
GO:0046580negative regulation of Ras protein signal transducIEAbiological_process


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