Phosphorylation

Protein information

UniProt/SwissProt ID:	DGKD_HUMAN
Description:	diacylglycerol kinase, delta 130kDa [Source:HGNC Symbol;Acc:2851]
Location:	chr2 q37.1
Node attribute:	substrate

Position	PhosphoPeptide	Catalytic kinase	Source
S66	TKQNNsFQRSK	PKCa	RegPhos
S66	TKQNNsFQRSK	PH	PhosphoSitePlus
S460	LPRQAsSSTVT		PhosphoSitePlus
S26	NSFQRsKRRYF	PRKCA	HPRD
Y757	PETLEyYTEKC		PhosphoSitePlus
S66	TKQNNsFQRSK	PKCa(PKC alpha	RegPhos
S66	TKQNNsFQRSK	PKC_alpha	phosphoELM
S70	NSFQRsKRRYF	PKC_alpha	phosphoELM
S70	NSFQRsKRRYF	PKCa	RegPhos
S70	NSFQRsKRRYF	PRKCA	HPRD
S70	NSFQRsKRRYF	PKCa(PKC alpha	RegPhos
S44	LIRKVsTSGQI		PhosphoSitePlus; SysPTM
S70	NSFQRsKRRYF	PH	PhosphoSitePlus
T440	LERAStKMLDR	DAGK_cat	PhosphoSitePlus
S615	MLRANsLKKAI		PhosphoSitePlus
S22	TKQNNsFQRSK	PRKCA	HPRD
T45	IRKVStSGQIR		PhosphoSitePlus
S66	TKQNNsFQRSK	PRKCA	HPRD

DGKD_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000264057	E789Q	COSMIC	Pancreatic Cancer
ENSP00000264057	H1156Q	COSMIC	Ovarian Cancer	21720365
ENSP00000264057	R80Q	COSMIC	Central Nervous System Neoplasms	18772890
ENSP00000386455	R36Q	TCGA	Neoplasms by Histologic Type	21720365, 18772890
ENSP00000264057	A450S	COSMIC	Lung Cancer
ENSP00000264057	T284I	COSMIC	Melanoma
ENSP00000264057	E628K	COSMIC	Central Nervous System Neoplasms	18772396

DGKD_HUMAN is not differential expressed protein.

DGKD_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
KPCA_HUMAN	DGKD_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)

KEGG Pathway

KEGG ID	Pathway
hsa01100	Metabolic pathways
hsa00561	Glycerolipid metabolism
hsa00564	Glycerophospholipid metabolism
hsa04070	Phosphatidylinositol signaling system

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0004143	diacylglycerol kinase activity	IDA	molecular_function
GO:0007165	signal transduction	TAS	biological_process
GO:0007173	epidermal growth factor receptor signaling pathway	NAS	biological_process
GO:0030168	platelet activation	TAS	biological_process
GO:0007205	protein kinase C-activating G-protein coupled rece	NAS	biological_process
GO:0005737	cytoplasm	IDA	cellular_component
GO:0007596	blood coagulation	TAS	biological_process
GO:0019992	diacylglycerol binding	NAS	molecular_function
GO:0010033	response to organic substance	IDA	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0016023	cytoplasmic membrane-bounded vesicle	IDA	cellular_component
GO:0046982	protein heterodimerization activity	IDA	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0035556	intracellular signal transduction	IEA	biological_process
GO:0051260	protein homooligomerization	IDA	biological_process
GO:0019932	second-messenger-mediated signaling	NAS	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0005886	plasma membrane	IDA	cellular_component
GO:0005543	phospholipid binding	IEA	molecular_function
GO:0015031	protein transport	IEA	biological_process
GO:0007275	multicellular organismal development	NAS	biological_process
GO:0046339	diacylglycerol metabolic process	IC	biological_process
GO:0016049	cell growth	NAS	biological_process
GO:0042803	protein homodimerization activity	IDA	molecular_function
GO:0006897	endocytosis	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network