Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DESP_HUMAN
Description:desmoplakin [Source:HGNC Symbol;Acc:3052]
Location:chr6 p24.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S176GYTCQsGSGWDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S2009TIRSSsFSDTLHPRD
S2708GKKKMsAAEAVPhosphoSitePlus
Y1391EDTSGyRAQIDPhosphoSitePlus
T2460TSQKNtLRKRRPlectinPhosphoSitePlus
T1714LTENLtKEHLMPhosphoSitePlus
S2867YSFSSsSIHPRD; phosphoELM
T2853GSFDAtGNSSYPhosphoSitePlus; HPRD; phosphoELM
S2857ATGNSsYSYSYHPRD; phosphoELM
Y2720EKWLPyEAGQRPhosphoSitePlus
S1127KRRRKsVEDRFPhosphoSitePlus; HPRD
S2868SFSSSsIGH__PhosphoSitePlus
Y2275QKLGIyEAMKIPlectinPhosphoSitePlus
S2269SFSSSsIHPRD
Y2817GLPSPyNMSSAPhosphoSitePlus; HPRD
S1952QYRSGsLSLTQHPRD
S2207SVQKRsMSFQGPhosphoSitePlus; HPRD; RegPhos
Y2087DRQQIyAAEKAPlectinPhosphoSitePlus
S2608TIRSSsFSDTLPhosphoSitePlus; HPRD; phosphoELM
S2209QKRSMsFQGIRPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y2731FLEFQyLTGGLPlectinPhosphoSitePlus
T1220NITKTtIKEISPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y172KGGGGyTCQSGPhosphoSitePlus; HPRD; phosphoELM
S2833GSRSGsRSGSRHPRD; phosphoELM
Y1199KVRNHyNEEMSPhosphoSitePlus
T2254GSFDAtGNSSYHPRD
S2007NLTIRsSSFSDHPRD
S2553RSGSLsLTQFAHPRD
Y1512LQRVQyDLQKAPhosphoSitePlus
S2849GSRRGsFDATGPhosphoSitePlus; phosphoELM; RegPhos
Y2547KFFDQyRSGSLPhosphoSitePlus
S2866SYSFSsSSIGHPhosphoSitePlus
S2071KLTVDsAIARDHPRD
T1613QAIKItNLTQQPhosphoSitePlus
S165RVRRAsSKGGGPhosphoSitePlus; HPRD; phosphoELM
S2226SSAPGsRSGSRHPRD
S2250GSRRGsFDATGHPRD
S2825SSAPGsRSGSRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1225TIKEIsMQKEDphosphoELM; RegPhos
S2849GSRRGsFDATGPKACaRegPhos
S1950FDQYRsGSLSLHPRD
Y1101NLDKCyGQIKEPhosphoSitePlus
S2606NLTIRsSSFSDPhosphoSitePlus; HPRD; phosphoELM
S1608SVQKRsMSFQGHPRD
S2030PKEKYsLVEAKPhosphoSitePlus
S442NLVNKsKKIVQPhosphoSitePlus
Y1740RAVTGyNDPETHPRD
S2849GSRRGsFDATGPRKACAHPRD
Y42TSRMYySRRGVPhosphoSitePlus
S1585LKRTAsEDSCKPhosphoSitePlus
S1438QKATGsEVSQRHPRD
Y2785KLKISyKDAINPhosphoSitePlus
S299LLYDWsDKNTNPhosphoSitePlus
S32RYEVTsGGGGTPhosphoSitePlus
S2221SPYNMsSAPGSHPRD
T1956GSLSLtQFADMHPRD
S246DLREKsAIYQLPhosphoSitePlus; HPRD; phosphoELM
S1425AGASAsPKEKYHPRD
Y28GPDLRyEVTSGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S2228APGSRsGSRSGHPRD
T2555GSLSLtQFADMHPRD; phosphoELM
Y1169IKEKEyEIERLPhosphoSitePlus
S2549FDQYRsGSLSLPhosphoSitePlus; HPRD
Y2858TGNSSySYSYSHPRD; phosphoELM
S1658ELRRLsSEVEAHPRD; phosphoELM
S2551QYRSGsLSLTQHPRD; phosphoELM
T31LRYEVtSGGGGPhosphoSitePlus
T1861TSQKNtLRKRRHPRD
T49RRGVItDQNSDPhosphoSitePlus
Y2218GLPSPyNMSSAHPRD
Y255QLEEEyENLLKPhosphoSitePlus
S2610RSSSFsDTLEEPhosphoSitePlus; HPRD; phosphoELM
T613IQSQFtDAQKHPhosphoSitePlus
Y1116ITRLTyEIEDEPhosphoSitePlus
S2849GSRRGsFDATGPKA_group RegPhos
S2011RSSSFsDTLEEHPRD
Y1139QQKNDyDQLQKPhosphoSitePlus
S2859GNSSYsYSYSFPhosphoSitePlus
T1996VSKIStISSVRHPRD
S914QDSLEsMKFGDPhosphoSitePlus
S2868SFSSSsIHPRD; phosphoELM
S2607LTIRSsSFSDTPhosphoSitePlus; HPRD; phosphoELM
S22MIRAEsGPDLRPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S1472KLTVDsAIARDHPRD
Y2275QKLGIyEAMKIHPRD; phosphoELM
Y41GTSRMyYSRRGPhosphoSitePlus
S2024AGASAsPKEKYPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T1183LQEEGtRKREYPhosphoSitePlus
T13HPRINtLGRMIPhosphoSitePlus
T2733EFQYLtGGLVDPlectinPhosphoSitePlus
T1415KRLKNtLTQTTHPRD
S166VRRASsKGGGGPhosphoSitePlus; HPRD; phosphoELM
T2603SVRNLtIRSSSPhosphoSitePlus; HPRD; phosphoELM
S53ITDQNsDGYCQPhosphoSitePlus
T2004SVRNLtIRSSSHPRD
Y56QNSDGyCQTGTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y2029SPKEKySLVEAPhosphoSitePlus
T2612SSFSDtLEESSPlectinPhosphoSitePlus
S2856DATGNsSYSYSPhosphoSitePlus; HPRD; phosphoELM
Y1676QKLGIyEAMKIHPRD
Y1542RLRIDyERVSQPhosphoSitePlus
T1319EEAAKtIQDKNPhosphoSitePlus
S2268YSFSSsSIHPRD
S2257DATGNsSYSYSHPRD
S1610QKRSMsFQGIRHPRD
S213GVDLAsVEQHIHPRD
S1841LNRAKsTLEAEERMPhosphoSitePlus
S2827APGSRsGSRSGHPRD; phosphoELM
S2258ATGNSsYSYSYHPRD
S2022SIAGAsASPKEPhosphoSitePlus
Y1065QNLQKyQAECSPhosphoSitePlus
S2008LTIRSsSFSDTHPRD
S2821PYNMSsAPGSRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S2234GSRSGsRSGSRHPRD
S610KRKIQsQFTDAPhosphoSitePlus
T1417LKNTLtQTTENHPRD
T173GGGGYtCQSGSPhosphoSitePlus; HPRD; phosphoELM
Y1981TAMQLyECQLIPhosphoSitePlus
T2460TSQKNtLRKRRHPRD
Y2259TGNSSySYSYSHPRD
S1418LRGAGsIAGASHPRD
S2526DRKTGsQYDIQPhosphoSitePlus
T2524LVDRKtGSQYDPhosphoSitePlus
S911KRRQDsLESMKPhosphoSitePlus
Y55DQNSDgYCQTGHPRD
S178TCQSGsGWDEFPhosphoSitePlus; HPRD; phosphoELM
T37SGGGGtSRMYYPhosphoSitePlus
S2829GSRSGsRSGSRPhosphoSitePlus; HPRD; phosphoELM
Y95QPELKyGDGIQPhosphoSitePlus
S2230GSRSGsRSGSRHPRD
S2815SKGLPsPYNMSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S2222PYNMSsAPGSRHPRD
Y2316PVEEAyKRGLVPlectinPhosphoSitePlus
Y249EKSAIyQLEEEPhosphoSitePlus
Y961NSIKDyELQLAPhosphoSitePlus
S157LYKAIsVPRVRPhosphoSitePlus; HPRD
Y231NSIGDyRWQLDPhosphoSitePlus
S1708IERLQsLTENLPhosphoSitePlus
S2849GSRRGsFDATGPKA_groupphosphoELM; RegPhos
S1954RSGSLsLTQFAHPRD
Y2159IDRDLyRSLNDPlectinPhosphoSitePlus
S2820SPYNMsSAPGSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y2339RAVTGyNDPETHPRD; SysPTM
T1420TLTQTtENLRRHPRD
Y2264CIAGIyNETTKPlectinPhosphoSitePlus
Y27SGPDLrYEVTSHPRD
T2595VSKIStISSVRHPRD
S2161RDLYRsLNDPRPlectinPhosphoSitePlus
S2216SKGLPsPYNMSHPRD
S2017LRGAGsIAGASHPRD
S1659LRRLSsEVEALPhosphoSitePlus
S2071KLTVDsAIARDPlectinPhosphoSitePlus

Dephosphorylation site
DESP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000396591S79FTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000396591R451CTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000369129I533MCOSMICHead and Neck Cancer21798893
ENSP00000369129R451CCOSMICCentral Nervous System Neoplasms18772890
ENSP00000369129H2871QBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000369129E1170KCOSMICMelanoma21499247
ENSP00000396591D288GTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000369129D960YBIOMARTBreast Cancer21930507, 21930502
ENSP00000369129T1536SCOSMICOvarian Cancer21720365
ENSP00000369129I2213MBIOMARTBreast Cancer21930507, 21930502
ENSP00000396591D960YBIOMARTBreast Cancer21930507, 21930502
ENSP00000396591P630LTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000396591R1333CBIOMARTBreast Cancer21930507, 21930502
ENSP00000369129D288GCOSMICCentral Nervous System Neoplasms18772890
ENSP00000369129N757SCOSMICHead and Neck Cancer21798893
ENSP00000369129R1932CBIOMARTBreast Cancer21930507, 21930502
ENSP00000369129R160GCOSMICHead and Neck Cancer21798893
ENSP00000396591I1614MBIOMARTBreast Cancer21930507, 21930502
ENSP00000369129R1302HCOSMICHead and Neck Cancer21798893
ENSP00000369129P630LCOSMICCentral Nervous System Neoplasms18772890
ENSP00000369129R1464KCOSMICHead and Neck Cancer21984974
ENSP00000369129S79FCOSMICCentral Nervous System Neoplasms18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000369129Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.118646787
ENSP00000369129Gastric CancerMetastasiscell lineUp1.617022644
ENSP00000369129Uterine CancerNormal vs. CancertissueDown17902640
ENSP00000369129Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000369129Small cell lung carcinomaTreatment (none vs. isogenic Doxorubicin-resistant)cell lineDown0.1518654985
ENSP00000369129Gastric CancerMetastasiscell lineUp1.617022644
ENSP00000369129Breast CancerNormal vs. Cancercell lineDown0.2420198662

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y56TDQNSDGyCQTGTMScholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANDESP_HUMANkinase -> substrateRegPhos
KPCA_HUMANDESP_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0002934desmosome organizationIEAbiological_process
GO:0003223ventricular compact myocardium morphogenesisIEAbiological_process
GO:0030216keratinocyte differentiationIDAbiological_process
GO:0003223ventricular compact myocardium morphogenesisISSbiological_process
GO:0005882intermediate filamentIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0008544epidermis developmentTASbiological_process
GO:0030057desmosomeIEAcellular_component
GO:0071896protein localization to adherens junctionISSbiological_process
GO:0001533cornified envelopeIDAcellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0005198structural molecule activityIDAmolecular_function
GO:0005080protein kinase C bindingIPImolecular_function
GO:0005856cytoskeletonIEAcellular_component
GO:0045104intermediate filament cytoskeleton organizationIEAbiological_process
GO:0045109intermediate filament organizationISSbiological_process
GO:0014704intercalated discIDAcellular_component
GO:0005882intermediate filamentISScellular_component
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0086091regulation of heart rate by cardiac conductionIMPbiological_process
GO:0018149peptide cross-linkingIDAbiological_process
GO:0005911cell-cell junctionIEAcellular_component
GO:0014704intercalated discIEAcellular_component
GO:0034332adherens junction organizationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0071896protein localization to adherens junctionIEAbiological_process
GO:0086069bundle of His cell to Purkinje myocyte communicatiIMPbiological_process
GO:0005200structural constituent of cytoskeletonTASmolecular_function
GO:0016337cell-cell adhesionIEAbiological_process
GO:0097110scaffold protein bindingIPImolecular_function
GO:0002934desmosome organizationISSbiological_process
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0006915apoptotic processTASbiological_process
GO:0043588skin developmentIEAbiological_process
GO:0086005regulation of ventricular cardiac muscle cell actiIMPbiological_process
GO:0045109intermediate filament organizationIEAbiological_process
GO:0030674protein binding, bridgingIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function