| UniProt/SwissProt ID: | DDX18_HUMAN |
| Description: | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 [Source:HGNC Symbol;Acc:2741] |
| Location: | chr2 q14.1 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T360 | PTRRQtMLFSA | DEAD | PhosphoSitePlus |
| T68 | VGLSEtQNGGM | GAGA_bind; CDC27 | PhosphoSitePlus |
| Y442 | SVKYHyELLNY | PhosphoSitePlus | |
| S74 | QNGGMsQEAVG | GAGA_bind; CDC27 | PhosphoSitePlus |
| S86 | IKVTKsPQKST | HPRD | |
| S227 | AAKTGsGKTLA | DEAD | PhosphoSitePlus |
| Y440 | CMSVKyHYELL | PhosphoSitePlus | |
| S2 | LPMK | HPRD | |
| T225 | LAAAKtGSGKT | HPRD | |
| T368 | FSATQtRKVED | DEAD | PhosphoSitePlus |
| S227 | AAKTGsGKTLA | HPRD | |
| S2 | ____MsHLPMK | PhosphoSitePlus | |
| T225 | LAAAKtGSGKT | DEAD | PhosphoSitePlus |
| S36 | SNLTLsETQNG | GAGA_bind; CDC27 | PhosphoSitePlus |
| T368 | FSATQtRKVED | HPRD | |
| S86 | IKVTKsPQKST | GAGA_bind; CDC27 | PhosphoSitePlus |
| Y385 | KKEPLyVGVDD | PhosphoSitePlus | |
| S74 | QNGGMsQEAVG | HPRD | |
| Y447 | YELLNyIDLPV | Helicase_C | PhosphoSitePlus |
| T230 | TGSGKtLAFLI | DEAD | PhosphoSitePlus |
| Dephosphorylation site |
| DDX18_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000263239 | L568S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000263239 | G41R | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974, 18428421 | ENSP00000263239 | E550K | COSMIC | Lung Cancer | ENSP00000263239 | L568S | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000263239 | K660N | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000263239 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 2.3 | 18646787 | ENSP00000263239 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 |
| Hyperphosphorylation site |
| DDX18_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MYC_HUMAN | DDX18_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| DDX18_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004004 | ATP-dependent RNA helicase activity | TAS | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0004386 | helicase activity | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |