Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DCC_HUMAN
Description:deleted in colorectal carcinoma [Source:HGNC Symbol;Acc:2701]
Location:chr18 q21.2
Node attribute:receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T479ERALNtTQPGSfn3PhosphoSitePlus
S811VPLYEsATTRSPhosphoSitePlus
T813LYESAtTRSITPhosphoSitePlus
Y809EGVPLyESATTPhosphoSitePlus
S1073NLIDRsTLNEPHerpes_gE; Sarcoglycan_2;PhosphoSitePlus
Y881SEVRLyTVRWRfn3PhosphoSitePlus
T814YESATtRSITDPhosphoSitePlus
T1074LIDRStLNEPPHerpes_gE; Sarcoglycan_2;PhosphoSitePlus
T521PIKVAtQPELQPhosphoSitePlus
T488GSLQLtVGNLKfn3PhosphoSitePlus
Y1420DSANVyEQDDLNeogenin_CPhosphoSitePlus
Y1363EPKVPyTPLLSNeogenin_CPhosphoSitePlus

Dephosphorylation site
DCC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000389140Q460ETCGAOvarian Cancer21720365, 18772890
ENSP00000389140E524DTCGAOvarian Cancer21720365, 18772890
ENSP00000389140T1016ABIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000389140P1375HHPIColorectal Cancer8188295
ENSP00000389140Q627*BIOMARTBreast Cancer21930507, 21930502
ENSP00000389140F1039SHPIColorectal Cancer16959974
ENSP00000389140M168TOMIM, HPIEsophageal Cancer8187090
ENSP00000389140R603CBIOMARTMelanoma21930507, 21930502
ENSP00000389140R661*TCGAOvarian Cancer21720365, 18772890
ENSP00000389140S595NTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000389140Breast CancerNormal vs. CancertissueDown0.2916470630

Hyperphosphorylation site
DCC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NET1_HUMANDCC_HUMANligand -> receptorHPMR
NET4_HUMANDCC_HUMANligand -> receptorHPMR
CASP3_HUMANDCC_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance
hsa05210Colorectal cancer
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003713transcription coactivator activityIEAmolecular_function
GO:2000171negative regulation of dendrite developmentTASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0048671negative regulation of collateral sproutingTASbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0045121membrane raftIEAcellular_component
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0032584growth cone membraneIEAcellular_component
GO:0042981regulation of apoptotic processTASbiological_process
GO:0001975response to amphetamineIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0038007netrin-activated signaling pathwayIEAbiological_process
GO:0030424axonIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0007409axonogenesisTASbiological_process
GO:0006917induction of apoptosisTASbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0033563dorsal/ventral axon guidanceIEAbiological_process
GO:0010976positive regulation of neuron projection developmeIEAbiological_process
GO:0004888transmembrane signaling receptor activityTASmolecular_function
GO:0042802identical protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0010977negative regulation of neuron projection developmeTASbiological_process
GO:0001764neuron migrationIEAbiological_process
GO:0005042netrin receptor activityIEAmolecular_function
GO:0021965spinal cord ventral commissure morphogenesisIEAbiological_process