| UniProt/SwissProt ID: | DAPK2_HUMAN |
| Description: | death-associated protein kinase 2 [Source:HGNC Symbol;Acc:2675] |
| Location: | chr15 q22.31 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y49 | STGLEyAAKFI | Pkinase; TFIIE_beta | PhosphoSitePlus |
| S318 | RRWKLsFSIVS | DAPK2 | HPRD; phosphoELM; RegPhos |
| S318 | RRWKLsFSIVS | autocatalysis | RegPhos |
| S367 | HPRRRsSTS__ | PhosphoSitePlus | |
| S368 | PRRRSsTS___ | PhosphoSitePlus | |
| S318 | RRWKLsFSIVS | PhosphoSitePlus | |
| S299 | MVRREsVVNLE | PhosphoSitePlus; HPRD | |
| S349 | LRNCEsDTEED | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| Dephosphorylation site |
| DAPK2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| DAPK2_HUMAN do not have mutation site. |
| Differential expressed protein |
| DAPK2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DAPK2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DAPK2_HUMAN | DAPK2_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | DAPK2_HUMAN | kinase -> substrate | RegPhos |
| AURKB_HUMAN | DAPK2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05219 | Bladder cancer |
| hsa05200 | Pathways in cancer |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0031410 | cytoplasmic vesicle | IEA | cellular_component |
| GO:0006917 | induction of apoptosis | IMP | biological_process |
| GO:0043276 | anoikis | IMP | biological_process |
| GO:0005516 | calmodulin binding | IDA | molecular_function |
| GO:0042981 | regulation of apoptotic process | TAS | biological_process |
| GO:0004683 | calmodulin-dependent protein kinase activity | TAS | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0010506 | regulation of autophagy | TAS | biological_process |
| GO:0046777 | protein autophosphorylation | TAS | biological_process |
| GO:0034423 | autophagic vacuole lumen | IEA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0007243 | intracellular protein kinase cascade | IDA | biological_process |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | TAS | molecular_function |