Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DAG1_HUMAN
Description:dystroglycan 1 (dystrophin-associated glycoprotein 1) [Source:HGNC Symbol;Acc:2666]
Location:chr3 p21.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T884RPKNMtPYRSPHPRD
Y892RSPPPyVPPSRCRegPhos
Y892RSPPPyVPP__DAG1PhosphoSitePlus
T790LEDQAtFIKKGHPRD
Y892RSPPPyVPPSrcRegPhos
T478TASPPtRIRTTPhosphoSitePlus
Y892RSPPPyVSRCHPRD; phosphoELM
S814PPPSSsMPLILDAG1PhosphoSitePlus
S888MTPYRsPPPYVDAG1PhosphoSitePlus
T469TKVSItRLETAPhosphoSitePlus
Y886KNMTPyRSPPPDAG1PhosphoSitePlus
S485IRTTTsGVPRGPhosphoSitePlus; HPRD
T203DLTKMtPKQRIPhosphoSitePlus
Y886KNMTPyRSPPPHPRD
S216LHRMRsFSEVEPhosphoSitePlus
Y863PNAPPyQPPPPDAG1PhosphoSitePlus
S888MTPYRsPPPYVHPRD
S218RMRSFsEVELHPhosphoSitePlus
S812SKPPPsSSMPLDAG1PhosphoSitePlus
T790LEDQAtFIKKGDAG1PhosphoSitePlus
T884RPKNMtPYRSPDAG1PhosphoSitePlus
S812SKPPPsSSMPLHPRD

Dephosphorylation site
DAG1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000312435P868SBIOMARTBreast Cancer21930507, 21930502
ENSP00000312435V656MCOSMICOvarian Cancer21720365
ENSP00000312435V228LTCGAOvarian Cancer21720365, 18772890
ENSP00000440590V228LTCGAOvarian Cancer21720365, 18772890
ENSP00000440705V228LTCGAOvarian Cancer21720365, 18772890
ENSP00000440590V656MTCGAOvarian Cancer21720365, 18772890
ENSP00000439334V656MTCGAOvarian Cancer21720365, 18772890
ENSP00000440705V656MTCGAOvarian Cancer21720365, 18772890
ENSP00000442600V656MTCGAOvarian Cancer21720365, 18772890
ENSP00000312435R311WBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000312435V228LCOSMICOvarian Cancer21720365
ENSP00000442600V228LTCGAOvarian Cancer21720365, 18772890
ENSP00000439334V228LTCGAOvarian Cancer21720365, 18772890
ENSP00000312435V656MTCGAOvarian Cancer21720365, 18772890
ENSP00000438421V656MTCGAOvarian Cancer21720365, 18772890
ENSP00000312435R541QBIOMARTBreast Cancer21930507, 21930502
ENSP00000438421V228LTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000312435Breast CancerNormal vs. CancertissueDown0.8316470630

Hyperphosphorylation site
DAG1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SRC_HUMANDAG1_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05416Viral myocarditis
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05414Dilated cardiomyopathy
hsa04512ECM-receptor interaction
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016010dystrophin-associated glycoprotein complexIDAcellular_component
GO:0060445branching involved in salivary gland morphogenesisIEAbiological_process
GO:0016011dystroglycan complexIEAcellular_component
GO:0007016cytoskeletal anchoring at plasma membraneIEAbiological_process
GO:0070938contractile ringIDAcellular_component
GO:0017166vinculin bindingIPImolecular_function
GO:0005925focal adhesionIDAcellular_component
GO:0045121membrane raftIEAcellular_component
GO:0042169SH2 domain bindingIDAmolecular_function
GO:0022011myelination in peripheral nervous systemIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0034453microtubule anchoringIMPbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0002011morphogenesis of an epithelial sheetIEAbiological_process
GO:0014044Schwann cell developmentIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0005856cytoskeletonIEAcellular_component
GO:0043237laminin-1 bindingISSmolecular_function
GO:0030175filopodiumIDAcellular_component
GO:0019048virus-host interactionIDAbiological_process
GO:0021682nerve maturationIEAbiological_process
GO:0051898negative regulation of protein kinase B signaling IMPbiological_process
GO:0051393alpha-actinin bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0015631tubulin bindingIDAmolecular_function
GO:0008307structural constituent of muscleIMPmolecular_function
GO:0005604basement membraneIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0030027lamellipodiumIDAcellular_component
GO:0043409negative regulation of MAPK cascadeIMPbiological_process
GO:0006509membrane protein ectodomain proteolysisIDAbiological_process
GO:0005654nucleoplasmIDAcellular_component
GO:0003779actin bindingIDAmolecular_function
GO:0033268node of RanvierIEAcellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0045211postsynaptic membraneIEAcellular_component
GO:0042383sarcolemmaIEAcellular_component
GO:0006607NLS-bearing substrate import into nucleusIDAbiological_process
GO:0060441epithelial tube branching involved in lung morphogIEAbiological_process
GO:0030336negative regulation of cell migrationIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016021integral to membraneIDAcellular_component
GO:0009279cell outer membraneIEAcellular_component


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