| UniProt/SwissProt ID: | CXL16_HUMAN |
| Description: | chemokine (C-X-C motif) ligand 16 [Source:HGNC Symbol;Acc:16642] |
| Location: | chr17 p13.2 |
| Node attribute: | ligand; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S45 | CGKRIsSDSPP | FeThRed_A | PhosphoSitePlus |
| S46 | GKRISsDSPPS | FeThRed_A | PhosphoSitePlus |
| S48 | RISSDsPPSVQ | FeThRed_A | PhosphoSitePlus |
| Dephosphorylation site |
| CXL16_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000293778 | L198V | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| CXL16_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CXL16_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CXL16_HUMAN | CXCR6_HUMAN | ligand -> receptor | HPMR |
| CXL16_HUMAN | CXCR6_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04062 | Chemokine signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0034341 | response to interferon-gamma | IEA | biological_process |
| GO:0006935 | chemotaxis | NAS | biological_process |
| GO:0034097 | response to cytokine stimulus | IDA | biological_process |
| GO:0048247 | lymphocyte chemotaxis | IEA | biological_process |
| GO:0005576 | extracellular region | NAS | cellular_component |
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0005044 | scavenger receptor activity | IEA | molecular_function |
| GO:0005615 | extracellular space | IDA | cellular_component |
| GO:0030335 | positive regulation of cell migration | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0016021 | integral to membrane | NAS | cellular_component |
| GO:0030307 | positive regulation of cell growth | IEA | biological_process |
| GO:0034612 | response to tumor necrosis factor | IEA | biological_process |
| GO:0008009 | chemokine activity | IEA | molecular_function |
| GO:0005102 | receptor binding | NAS | molecular_function |
| GO:0006898 | receptor-mediated endocytosis | NAS | biological_process |
| GO:0005041 | low-density lipoprotein receptor activity | IEA | molecular_function |