| UniProt/SwissProt ID: | CUL5_HUMAN |
| Description: | cullin 5 [Source:HGNC Symbol;Acc:2556] |
| Location: | chr11 q22.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S539 | GAWSRsSEKVF | HPRD | |
| S730 | MRKKIsNAQLQ | Cullin_Nedd8 | PhosphoSitePlus |
| S128 | GSNKKsNVEDS | Cullin | PhosphoSitePlus |
| S124 | MGKQGsNKKSN | Cullin | PhosphoSitePlus |
| Y373 | ARDKAyKAVVN | HPRD; phosphoELM; RegPhos | |
| T346 | VEQLLtLFNRF | HPRD | |
| S539 | GAWSRsSEKVF | Cullin | PhosphoSitePlus |
| Y373 | ARDKAyKAVVN | Cullin | PhosphoSitePlus |
| S730 | MRKKIsNAQLQ | PRKACA | HPRD |
| T210 | AYLDStERFYR | HPRD; phosphoELM | |
| T210 | AYLDStERFYR | Cullin | PhosphoSitePlus |
| T346 | VEQLLtLFNRF | Cullin | PhosphoSitePlus |
| S730 | MRKKIsNAQLQ | PKA_group | phosphoELM; RegPhos |
| S34 | LLRQEsVTKQQ | Cullin | PhosphoSitePlus |
| S730 | MRKKIsNAQLQ | PKACa | RegPhos |
| Dephosphorylation site |
| CUL5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000435376 | C188F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000435376 | C188F | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000376808 | C188F | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000376808 | C188F | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| CUL5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CUL5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | CUL5_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | CUL5_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04120 | Ubiquitin mediated proteolysis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005262 | calcium channel activity | TAS | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0016567 | protein ubiquitination | IEA | biological_process |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0070588 | calcium ion transmembrane transport | TAS | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0031625 | ubiquitin protein ligase binding | IDA | molecular_function |
| GO:0016032 | viral reproduction | TAS | biological_process |
| GO:0051480 | cytosolic calcium ion homeostasis | IEA | biological_process |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0006970 | response to osmotic stress | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0031466 | Cul5-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0007050 | cell cycle arrest | TAS | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0031461 | cullin-RING ubiquitin ligase complex | IEA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0097193 | intrinsic apoptotic signaling pathway | TAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |