Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CUL5_HUMAN
Description:cullin 5 [Source:HGNC Symbol;Acc:2556]
Location:chr11 q22.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S539GAWSRsSEKVFHPRD
S730MRKKIsNAQLQCullin_Nedd8PhosphoSitePlus
S128GSNKKsNVEDSCullinPhosphoSitePlus
S124MGKQGsNKKSNCullinPhosphoSitePlus
Y373ARDKAyKAVVNHPRD; phosphoELM; RegPhos
T346VEQLLtLFNRFHPRD
S539GAWSRsSEKVFCullinPhosphoSitePlus
Y373ARDKAyKAVVNCullinPhosphoSitePlus
S730MRKKIsNAQLQPRKACAHPRD
T210AYLDStERFYRHPRD; phosphoELM
T210AYLDStERFYRCullinPhosphoSitePlus
T346VEQLLtLFNRFCullinPhosphoSitePlus
S730MRKKIsNAQLQPKA_groupphosphoELM; RegPhos
S34LLRQEsVTKQQCullinPhosphoSitePlus
S730MRKKIsNAQLQPKACaRegPhos

Dephosphorylation site
CUL5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000435376C188FCOSMICOvarian Cancer21720365
ENSP00000435376C188FTCGAOvarian Cancer21720365, 18772890
ENSP00000376808C188FTCGAOvarian Cancer21720365, 18772890
ENSP00000376808C188FCOSMICOvarian Cancer21720365

Differential expressed protein
CUL5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CUL5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANCUL5_HUMANkinase -> substrateRegPhos
KPCA_HUMANCUL5_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04120Ubiquitin mediated proteolysis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005262calcium channel activityTASmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0016567protein ubiquitinationIEAbiological_process
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0070588calcium ion transmembrane transportTASbiological_process
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0031625ubiquitin protein ligase bindingIDAmolecular_function
GO:0016032viral reproductionTASbiological_process
GO:0051480cytosolic calcium ion homeostasisIEAbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0006970response to osmotic stressIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0031466Cul5-RING ubiquitin ligase complexIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0007050cell cycle arrestTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0006511ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0004872receptor activityTASmolecular_function
GO:0031461cullin-RING ubiquitin ligase complexIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0097193intrinsic apoptotic signaling pathwayTASbiological_process
GO:0005737cytoplasmIEAcellular_component


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