| UniProt/SwissProt ID: | CSF3R_HUMAN |
| Description: | colony stimulating factor 3 receptor (granulocyte) [Source:HGNC Symbol;Acc:2439] |
| Location: | chr1 p34.3 |
| Node attribute: | substrate; receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y779 | SDQVLyGQLLG | HCK | HPRD |
| Y787 | PSPKSyENLWF | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y196 | KHLLLyQNMGI | EpoR_lig-bind | PhosphoSitePlus |
| Y814 | PSPKSyENLWF | HCK | HPRD |
| Y727 | TLVQTyVLQGD | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y767 | PGPGHyLRCDS | PhosphoSitePlus; phosphoELM; RegPhos | |
| S783 | AGLTPsPKSYE | PhosphoSitePlus | |
| Y752 | SDQVLyGQLLG | HCK | HPRD; RegPhos |
| Y752 | SDQVLyGQLLG | PhosphoSitePlus; phosphoELM; RegPhos | |
| T781 | LLAGLtPSPKS | PhosphoSitePlus | |
| Y787 | PSPKSyENLWF | HCK | HPRD; RegPhos |
| T351 | QLDPRtVQLFW | fn3 | PhosphoSitePlus |
| S365 | PLEEDsGRIQG | fn3 | PhosphoSitePlus |
| Dephosphorylation site |
| CSF3R_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000362195 | E480K | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000362195 | E363D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000362195 | T717M | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000362195 | M696I | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000362195 | D172N | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| CSF3R_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CSF3R_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSF2_HUMAN | CSF3R_HUMAN | ligand -> receptor | HPMR |
| ZAGL2_HUMAN | CSF3R_HUMAN | kinase -> substrate | RegPhos |
| HCK_HUMAN | CSF3R_HUMAN | kinase -> substrate | RegPhos |
| CSF3_HUMAN | CSF3R_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa05200 | Pathways in cancer |
| hsa04630 | Jak-STAT signaling pathway |
| hsa04640 | Hematopoietic cell lineage |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0004896 | cytokine receptor activity | IEA | molecular_function |
| GO:0030593 | neutrophil chemotaxis | IEA | biological_process |
| GO:0006952 | defense response | TAS | biological_process |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0007165 | signal transduction | NAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0042475 | odontogenesis of dentin-containing tooth | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |