Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CSF1_HUMAN
Description:colony stimulating factor 1 (macrophage) [Source:HGNC Symbol;Acc:2432]
Location:chr1 p13.3
Node attribute:ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S461EGGPAsEGAARHPRD
S426AQPQLsRSHSSCSF-1PhosphoSitePlus
S348FLSASsPLPASCSF-1PhosphoSitePlus
S353SPLPAsAKGQQCSF-1PhosphoSitePlus
S345PSNFLsASSPLCSF-1PhosphoSitePlus
S420NPSTLsAQPQLCSF-1PhosphoSitePlus

Dephosphorylation site
CSF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358817V135ICOSMICOvarian Cancer21720365
ENSP00000358817P410LCOSMICSkin Cancer21984974
ENSP00000358816V434MBIOMARTGastric Cancer21930507, 21930502
ENSP00000358817R449LCOSMICHepatocellular Carcinoma21822264
ENSP00000358817V135ITCGAOvarian Cancer21720365, 18772890
ENSP00000327513V135ITCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000358817Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.0615169874

Hyperphosphorylation site
CSF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSF1_HUMANCSF1R_HUMANligand -> receptorHPMR
CSF1_HUMANCSF1R_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa04640Hematopoietic cell lineage
hsa05323Rheumatoid arthritis
hsa04380Osteoclast differentiation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042117monocyte activationNASbiological_process
GO:0030225macrophage differentiationIEAbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0030278regulation of ossificationIEAbiological_process
GO:0045087innate immune responseIEAbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0042476odontogenesisIEAbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0042488positive regulation of odontogenesis of dentin-conIEAbiological_process
GO:0030154cell differentiationNASbiological_process
GO:0032946positive regulation of mononuclear cell proliferatIDAbiological_process
GO:0010743regulation of macrophage derived foam cell differeNASbiological_process
GO:0001954positive regulation of cell-matrix adhesionIEAbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0030097hemopoiesisNASbiological_process
GO:0043235receptor complexIEAcellular_component
GO:0048873homeostasis of number of cells within a tissueIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0045860positive regulation of protein kinase activityIEAbiological_process
GO:0060444branching involved in mammary gland duct morphogenIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0003006developmental process involved in reproductionIEAbiological_process
GO:0001503ossificationIEAbiological_process
GO:0005157macrophage colony-stimulating factor receptor bindIEAmolecular_function
GO:0060611mammary gland fat developmentIEAbiological_process
GO:0010744positive regulation of macrophage derived foam celIDAbiological_process
GO:0060763mammary duct terminal end bud growthIEAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0010628positive regulation of gene expressionIDAbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0005125cytokine activityIEAmolecular_function
GO:0045651positive regulation of macrophage differentiationIEAbiological_process
GO:0032270positive regulation of cellular protein metabolic IDAbiological_process
GO:0045672positive regulation of osteoclast differentiationIEAbiological_process
GO:0046579positive regulation of Ras protein signal transducIEAbiological_process
GO:0045657positive regulation of monocyte differentiationIEAbiological_process
GO:0030316osteoclast differentiationIDAbiological_process
GO:0016020membraneNAScellular_component
GO:0040018positive regulation of multicellular organism growIEAbiological_process