Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CSF1R_HUMAN
Description:colony stimulating factor 1 receptor [Source:HGNC Symbol;Acc:2433]
Location:chr5 q32
Node attribute:substrate; kinase; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S555WKIIEsYEGNSBravo_FIGEYPhosphoSitePlus
Y809MNDSNyIVKGNCSF1RHPRD; phosphoELM
T567TFIDPtQLPYNBravo_FIGEYPhosphoSitePlus
Y561YEGNSyTFIDPBravo_FIGEYPhosphoSitePlus
S560SYEGNsYTFIDBravo_FIGEYPhosphoSitePlus
S713YVRRDsGFSSQPkinase_TyrPhosphoSitePlus
Y708HLEKKyVRRDSPkinase_TyrPhosphoSitePlus
T363DTYRHtFTLSLI-setPhosphoSitePlus
Y809MNDSNyIVKGNphosphoELM
S686AMLGPsLSPGQPkinase_TyrPhosphoSitePlus
Y571PTQLPyNEKWEBravo_FIGEYPhosphoSitePlus
T562EGNSYtFIDPTBravo_FIGEYPhosphoSitePlus
Y809MNDSNyIVKGNautocatalysis RegPhos
Y546KQKPKyQVRWKBravo_FIGEYPhosphoSitePlus
Y873LVKDGyQMAQPPkinase_TyrPhosphoSitePlus
Y723QGVDTyVEMRPPkinase_TyrPhosphoSitePlus
T567TFIDPtQLPYNRegPhos
S716RDSGFsSQGVDPkinase_TyrPhosphoSitePlus
Y699EGGVDyKNIHLPkinase_TyrPhosphoSitePlus
Y708HLEKKyVRRDSautocatalysis RegPhos
Y556KIIESyEGNSYRegPhos
Y556KIIESyEGNSYBravo_FIGEYPhosphoSitePlus
Y809MNDSNyIVKGNFMSRegPhos
Y708HLEKKyVRRDSphosphoELM; RegPhos
Y723QGVDTyVEMRPHPRD; phosphoELM; RegPhos
Y561YEGNSyTFIDPFMS(CSF1RRegPhos
Y699EGGVDyKNIHLphosphoELM; RegPhos
T562EGNSYtFIDPTRegPhos
T365YRHTFtLSLPRI-setPhosphoSitePlus
S555WKIIEsYEGNSRegPhos
Y809MNDSNyIVKGNFMS(CSF1RRegPhos
Y809MNDSNyIVKGNPkinase_TyrPhosphoSitePlus
Y561YEGNSyTFIDPCSF1RphosphoELM
Y699EGGVDyKNIHLautocatalysis RegPhos
Y923RRERDyTNLPSPhosphoSitePlus
S178QDYQCsALMGGPhosphoSitePlus
S688LGPSLsPGQDPPkinase_TyrPhosphoSitePlus

Dephosphorylation site
CSF1R_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000286301P693HGreenman2007, HPILung Cancer17344846, 18428421
ENSP00000286301V279MBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000286301H506QDing2008Lung Cancer18948947
ENSP00000286301G340VBIOMARTBreast Cancer21930507, 21930502
ENSP00000286301G413SDing2008Lung Cancer12580961, 18428421, 18948947
ENSP00000286301G413SDing2008Neoplasms by Histologic Type12580961, 18428421, 18948947

Differential expressed protein
CSF1R_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CSF1R_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSF1_HUMANCSF1R_HUMANligand -> receptorHPMR
ZAGL2_HUMANCSF1R_HUMANkinase -> substrateRegPhos
CSF1R_HUMANCSF1R_HUMANkinase -> substrateRegPhos
CSF1_HUMANCSF1R_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa05200Pathways in cancer
hsa04144Endocytosis
hsa05202Transcriptional misregulation in cancer
hsa04380Osteoclast differentiation
hsa04640Hematopoietic cell lineage

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:2000147positive regulation of cell motilityIMPbiological_process
GO:0060603mammary gland duct morphogenesisTASbiological_process
GO:0071345cellular response to cytokine stimulusIEAbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0008283cell proliferationIMPbiological_process
GO:0045087innate immune responseIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayIMPbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0036006cellular response to macrophage colony-stimulatingIMPbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0045217cell-cell junction maintenanceIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0071902positive regulation of protein serine/threonine kiIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0036006cellular response to macrophage colony-stimulatingIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0031529ruffle organizationIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0004714transmembrane receptor protein tyrosine kinase actIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0030097hemopoiesisIMPbiological_process
GO:0042517positive regulation of tyrosine phosphorylation ofIEAbiological_process
GO:0030316osteoclast differentiationIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingIEAbiological_process
GO:0061098positive regulation of protein tyrosine kinase actIMPbiological_process
GO:0019955cytokine bindingIEAmolecular_function
GO:0043235receptor complexIEAcellular_component
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0038145macrophage colony-stimulating factor signaling patIMPbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0071345cellular response to cytokine stimulusISSbiological_process
GO:0008360regulation of cell shapeIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0005011macrophage colony-stimulating factor receptor actiIEAmolecular_function
GO:0007275multicellular organismal developmentTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0030225macrophage differentiationTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0001934positive regulation of protein phosphorylationIMPbiological_process
GO:0046488phosphatidylinositol metabolic processIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0030224monocyte differentiationTASbiological_process
GO:0090197positive regulation of chemokine secretionIMPbiological_process
GO:0045124regulation of bone resorptionISSbiological_process
GO:2000249regulation of actin cytoskeleton reorganizationIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process