| UniProt/SwissProt ID: | CRTC3_HUMAN |
| Description: | CREB regulated transcription coactivator 3 [Source:HGNC Symbol;Acc:26148] |
| Location: | chr15 q26.1 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S329 | LQSSRsNPSIQ | PhosphoSitePlus; HPRD | |
| S432 | DRSQLsFLPTE | PhosphoSitePlus | |
| T168 | DSALHtSALST | RegPhos | |
| T160 | SALNRtNSDSA | RegPhos | |
| S4 | GSGS | HPRD; SysPTM | |
| S305 | MSVGNsVNNIP | RegPhos | |
| S413 | QLSSTsPLAPY | PhosphoSitePlus | |
| S411 | SRQLSsTSPLA | PhosphoSitePlus; HPRD | |
| S62 | QYHGGsLPNVS | HPRD; RegPhos | |
| S162 | LNRTNsDSALH | TORC_M | PhosphoSitePlus |
| S391 | RQPPVsPLTLS | PhosphoSitePlus; HPRD; RegPhos | |
| T577 | SLNVDtPFPLE | TORC_C | PhosphoSitePlus |
| T412 | RQLSStSPLAP | PhosphoSitePlus | |
| S410 | FSRQLsSTSPL | PhosphoSitePlus; HPRD; RegPhos | |
| S4 | __MAAsPGSGS | PhosphoSitePlus; SysPTM | |
| S238 | EIQSLsGRPRS | TORC_M | PhosphoSitePlus |
| S406 | AHQGFsRQLSS | PhosphoSitePlus | |
| S373 | SLSNPsLSTTN | PhosphoSitePlus | |
| Y58 | LRLTQyHGGSL | TORC_N | PhosphoSitePlus |
| S396 | SPLTLsPGPEA | PhosphoSitePlus; HPRD; RegPhos; SysPTM | |
| S443 | AQAQVsPPPPY | PhosphoSitePlus; HPRD; SysPTM | |
| S368 | SLRLFsLSNPS | PhosphoSitePlus | |
| S375 | SNPSLsTTNLS | PhosphoSitePlus | |
| T394 | PVSPLtLSPGP | PhosphoSitePlus; HPRD; RegPhos | |
| S353 | NHPQTsVPNAS | PhosphoSitePlus | |
| S344 | KTVLSsSLNNH | PhosphoSitePlus | |
| T455 | APQELtQPLLQ | PhosphoSitePlus | |
| S524 | LVQQGsRELQD | PhosphoSitePlus | |
| S129 | GANYSsQPLDE | RegPhos | |
| T160 | SALNRtNSDSA | TORC_M | PhosphoSitePlus |
| S321 | LGIRSsSGLQS | TORC_M | PhosphoSitePlus |
| S345 | TVLSSsLNNHP | PhosphoSitePlus | |
| S363 | SALHPsLRLFS | PhosphoSitePlus | |
| S62 | QYHGGsLPNVS | TORC_N | PhosphoSitePlus |
| Y448 | SPPPPyPAPQE | PhosphoSitePlus | |
| S370 | RLFSLsNPSLS | PhosphoSitePlus | |
| T352 | NNHPQtSVPNA | PhosphoSitePlus | |
| S305 | MSVGNsVNNIP | TORC_M | PhosphoSitePlus |
| S543 | YSNCGsLPNTI | RegPhos | |
| S162 | LNRTNsDSALH | NuaK2 | RegPhos |
| S135 | QPLDEsWPRQQ | PhosphoSitePlus | |
| Dephosphorylation site |
| CRTC3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000268184 | R70Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000416573 | R70Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000416573 | N158K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000268184 | *620Y | COSMIC | Intestines Cancer | 16959974 | ENSP00000268184 | N158K | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| CRTC3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CRTC3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | CRTC3_HUMAN | kinase -> substrate | RegPhos |
| CRTC3_HUMAN | IL8_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05166 | HTLV-I infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0008140 | cAMP response element binding protein binding | IEA | molecular_function |
| GO:0051289 | protein homotetramerization | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0032793 | positive regulation of CREB transcription factor a | IEA | biological_process |