| UniProt/SwissProt ID: | COR1B_HUMAN |
| Description: | coronin, actin binding protein, 1B [Source:HGNC Symbol;Acc:2253] |
| Location: | chr11 q13.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y26 | KNDQCyEDIRV | DUF1899 | PhosphoSitePlus |
| S413 | RRNVLsDSRPA | HPRD | |
| S199 | ACKDKsVRIID | WD40 | PhosphoSitePlus |
| S2 | RKVV | PRKCA | HPRD |
| S2 | ____MsFRKVV | PhosphoSitePlus | |
| S2 | MSFRKvV | PKCa | RegPhos |
| S2 | MSFRKvV | PKC_group | RegPhos |
| S66 | LVLPLsKTGRI | DUF1899 | PhosphoSitePlus |
| T209 | DPRRGtLVAER | PhosphoSitePlus | |
| T439 | TAADAtPSGSL | PhosphoSitePlus | |
| S381 | AEEWVsGRDAD | HPRD | |
| Dephosphorylation site |
| COR1B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000340211 | V411M | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000377471 | V411M | HPI | Colorectal Cancer | 16959974 | ENSP00000377471 | V411M | Sjoblom2006 | Intestines Cancer | 16959974 | ENSP00000340211 | V411M | HPI | Colorectal Cancer | 16959974 | ENSP00000340211 | R33C | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000377471 | Breast Cancer | Treatment (tamoxifen-sensitive vs. tamoxifen-resistant) | tissue | Up | 2.4 | 19329653 |
| Hyperphosphorylation site |
| COR1B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | COR1B_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| COR1B_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0015629 | actin cytoskeleton | IBA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051015 | actin filament binding | IBA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0030036 | actin cytoskeleton organization | IBA | biological_process |