Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:COIA1_HUMAN
Description:collagen, type XVIII, alpha 1 [Source:HGNC Symbol;Acc:2195]
Location:chr21 q22.3
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1245EPGDAsLGFGMPhosphoSitePlus
T1450VRLWAtRQAMLEndostatinPhosphoSitePlus

Dephosphorylation site
COIA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000347665L356PCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000352798Breast CancerNormal vs. CancertissueDown0.5620739354
ENSP00000352798Renal CancerNormal vs. CancertissueDown19164279
ENSP00000352798Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
COIA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
COIA1_HUMANGPC1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04974Protein digestion and absorption

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0005604basement membraneIEAcellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0005581collagenIEAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0001525angiogenesisIEAbiological_process
GO:0001886endothelial cell morphogenesisIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0005198structural molecule activityIEAmolecular_function
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0030198extracellular matrix organizationTASbiological_process
GO:0007601visual perceptionTASbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0005788endoplasmic reticulum lumenTAScellular_component
GO:0009887organ morphogenesisTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0031012extracellular matrixIDAcellular_component
GO:0005615extracellular spaceIDAcellular_component
GO:0007155cell adhesionIEAbiological_process
GO:0030198extracellular matrix organizationIEAbiological_process


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