| UniProt/SwissProt ID: | CO4A3_HUMAN |
| Description: | collagen, type IV, alpha 3 (Goodpasture antigen) [Source:HGNC Symbol;Acc:2204] |
| Location: | chr2 q36.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T243 | PGPPGtVIVTL | Collagen | PhosphoSitePlus |
| S382 | PGVPGsPGSSR | Collagen | PhosphoSitePlus |
| T1443 | PATWTtRGFVF | PhosphoSitePlus | |
| T835 | GRRGKtGPKGD | Collagen | PhosphoSitePlus |
| S1452 | VFTRHsQTTAI | C4 | PhosphoSitePlus |
| S1435 | GKRGDsGSPAT | Collagen | PhosphoSitePlus |
| S1648 | RKPIPsTVKAG | C4 | PhosphoSitePlus |
| T249 | VIVTLtGPDNR | PhosphoSitePlus | |
| T235 | GVKGLtGPPGP | Collagen | PhosphoSitePlus |
| T1649 | KPIPStVKAGE | C4 | PhosphoSitePlus |
| Dephosphorylation site |
| CO4A3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000379823 | P858L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000379823 | S948Y | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000379823 | E131K | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000379823 | P858L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000379823 | P513S | COSMIC | Skin Cancer | 21984974 | ENSP00000379823 | C1551R | BIOMART | chronic lymphocytic leukemia | 21930507, 21930502 | ENSP00000379823 | L882* | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000379823 | Breast Cancer | Metastasis | tissue | Up | 18257521 | |
| Hyperphosphorylation site |
| CO4A3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KCC2B_HUMAN | CO4A3_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| CO4A3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006917 | induction of apoptosis | IDA | biological_process |
| GO:0016525 | negative regulation of angiogenesis | IEA | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0005201 | extracellular matrix structural constituent | IEA | molecular_function |
| GO:0008191 | metalloendopeptidase inhibitor activity | NAS | molecular_function |
| GO:0016525 | negative regulation of angiogenesis | IDA | biological_process |
| GO:0006919 | activation of cysteine-type endopeptidase activity | IDA | biological_process |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0005587 | collagen type IV | IEA | cellular_component |
| GO:0008283 | cell proliferation | IDA | biological_process |
| GO:0008015 | blood circulation | TAS | biological_process |
| GO:0032836 | glomerular basement membrane development | IEA | biological_process |
| GO:0005587 | collagen type IV | IDA | cellular_component |
| GO:0005788 | endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0005581 | collagen | IEA | cellular_component |
| GO:0005604 | basement membrane | IDA | cellular_component |
| GO:0032836 | glomerular basement membrane development | ISS | biological_process |
| GO:0030198 | extracellular matrix organization | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | NAS | biological_process |
| GO:0005198 | structural molecule activity | NAS | molecular_function |
| GO:0005178 | integrin binding | TAS | molecular_function |
| GO:0007605 | sensory perception of sound | TAS | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | IEA | biological_process |