| UniProt/SwissProt ID: | CNKR1_HUMAN |
| Description: | connector enhancer of kinase suppressor of Ras 1 [Source:HGNC Symbol;Acc:19700] |
| Location: | chr1 p36.11 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S300 | PQVLDsPHQRS | PhosphoSitePlus | |
| S307 | HQRSPsLSLAP | PhosphoSitePlus; phosphoELM | |
| S300 | HQRSPsLSLAP | HPRD | |
| S307 | SLAPLsPRAPS | HPRD | |
| T289 | IPIPEtPPQTP | PhosphoSitePlus | |
| S314 | SLAPLsPRAPS | PhosphoSitePlus; phosphoELM; SysPTM | |
| S278 | EPAGLsLVLKK | PhosphoSitePlus | |
| S305 | SPHQRsPSLSL | PhosphoSitePlus; phosphoELM | |
| Y456 | INVSNySLESG | PH | PhosphoSitePlus |
| T293 | ETPPQtPPQVL | PhosphoSitePlus | |
| S298 | SPHQRsPSLSL | HPRD | |
| S385 | LATRLsRRRVS | NME1 | HPRD |
| Dephosphorylation site |
| CNKR1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000354609 | W486* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000354609 | A503T | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000354609 | H687Y | COSMIC | Renal Cancer | 20054297 |
| Differential expressed protein |
| CNKR1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CNKR1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NDKA_HUMAN | CNKR1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| CNKR1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005938 | cell cortex | IDA | cellular_component |
| GO:0007265 | Ras protein signal transduction | IPI | biological_process |
| GO:0007169 | transmembrane receptor protein tyrosine kinase sig | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007266 | Rho protein signal transduction | IPI | biological_process |
| GO:0005911 | cell-cell junction | TAS | cellular_component |
| GO:0016301 | kinase activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0030674 | protein binding, bridging | IDA | molecular_function |