| UniProt/SwissProt ID: | CLTR2_HUMAN |
| Description: | cysteinyl leukotriene receptor 2 [Source:HGNC Symbol;Acc:18274] |
| Location: | chr13 q14.2 |
| Node attribute: | GPCR |
| Phosphorylation site |
| CLTR2_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| CLTR2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000282018 | V207M | COSMIC | Skin Cancer | 21984974 | ENSP00000282018 | *347S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000282018 | R100K | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000282018 | *347C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000282018 | K327N | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000282018 | W104* | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| CLTR2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CLTR2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CLTR2_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| CLTR2_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04020 | Calcium signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006955 | immune response | NAS | biological_process |
| GO:0050909 | sensory perception of taste | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005575 | cellular_component | ND | cellular_component |
| GO:0001631 | cysteinyl leukotriene receptor activity | IEA | molecular_function |
| GO:0010942 | positive regulation of cell death | IEA | biological_process |
| GO:0045766 | positive regulation of angiogenesis | IEA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0004974 | leukotriene receptor activity | NAS | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |