Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CLH1_HUMAN
Description:clathrin, heavy chain (Hc) [Source:HGNC Symbol;Acc:2092]
Location:chr17 q23.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1016IVLDNsVFSEHHPRD
Y1513RRIAAyLFKGNClathrinPhosphoSitePlus
T1482YQALRtSIDAYClathrinPhosphoSitePlus
Y1673QPGFGySM___PhosphoSitePlus
Y1477ITEEDyQALRTClathrinPhosphoSitePlus
Y634HFTDLyDIKRAClathrinPhosphoSitePlus
Y1237VHLGEyQAAVDClathrinPhosphoSitePlus
Y900RENPYyDSRVVClathrinPhosphoSitePlus
S1618LDASEsLRKEEPhosphoSitePlus
S672LRAMLsANIRQHPRD
T397LRTPDtIRRFQClathrin_H_linkPhosphoSitePlus
S412QPGQTsPLLQYHPRD
Y1477ITEEDyQALRTSRCphosphoELM
T394KGILRtPDTIRHPRD; phosphoELM; RegPhos; SysPTM
Y1487TSIDAyDNFDNClathrinPhosphoSitePlus
S1440AVNYFsKVKQLClathrinPhosphoSitePlus
T411AQPGQtSPLLQHPRD
S1616DKLDAsESLRKHPRD
T1608MKEYLtKVDKLPhosphoSitePlus
Y1634TQPIVyGQPQLPhosphoSitePlus
S672LRAMLsANIRQClathrinPhosphoSitePlus
Y1657QAPFGyGYTAPPhosphoSitePlus
S1016IVLDNsVFSEHClathrinPhosphoSitePlus
Y1218AAKLLyNNVSNClathrinPhosphoSitePlus
Y1659PFGYGyTAPPYPhosphoSitePlus
T1180FALAKtNRLAECoatomer_WDAD; ClathrinPhosphoSitePlus
Y899LRENPyYDSRVClathrinPhosphoSitePlus
Y1211YDEKMyDAAKLClathrinPhosphoSitePlus
Y634HFTDLyDIKRAHPRD; phosphoELM
T473KSVDPtLALSVPhosphoSitePlus
Y883ALAKIyIDSNNClathrinPhosphoSitePlus
Y1438TRAVNyFSKVKClathrinPhosphoSitePlus
S1229FGRLAsTLVHLClathrinPhosphoSitePlus
T1396FKDIItKVANVClathrinPhosphoSitePlus
Y556DVFMEyNLIQQClathrinPhosphoSitePlus
S1494NFDNIsLAQRLHPRD; phosphoELM; RegPhos; SysPTM
Y1096NLDRAyEFAERClathrin; Coatomer_WDADPhosphoSitePlus
Y1477ITEEDyQALRTSrcRegPhos
S1222LYNNVsNFGRLClathrinPhosphoSitePlus
Y510AKKVGyTPDWIPhosphoSitePlus
Y1206VGDRCyDEKMYClathrinPhosphoSitePlus
Y899LRENPyYDSRVHPRD; phosphoELM
S1019DNSVFsEHRNLClathrinPhosphoSitePlus
Y1477ITEEDyQALRTHPRD; RegPhos
T158IINYRtDAKQKClathrin_propelPhosphoSitePlus
Y1664YTAPPyGQPQPPhosphoSitePlus
S902NPYYDsRVVGKClathrinPhosphoSitePlus
Y799NNLQKyIEIYVClathrinPhosphoSitePlus
T1660FGYGYtAPPYGPhosphoSitePlus
S1494NFDNIsLAQRLClathrinPhosphoSitePlus; SysPTM
T394KGILRtPDTIRClathrin_H_linkPhosphoSitePlus; SysPTM
T105KAHTMtDDVTFClathrin_propelPhosphoSitePlus
S1019DNSVFsEHRNLHPRD
Y883ALAKIyIDSNNHPRD
T1230GRLAStLVHLGClathrinPhosphoSitePlus

Dephosphorylation site
CLH1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000269122Y1289CTCGAOvarian Cancer21720365, 18772890
ENSP00000269122Y1289CCOSMICOvarian Cancer21720365
ENSP00000269122A1595VCOSMICBreast Cancer20668451
ENSP00000269122E195KBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000269122Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000269122Breast CancerTreatment (mitoxantrone-sensitive vs. mitoxantrone-resistant)cell lineUp3.716335961
ENSP00000269122Hepatocellular CarcinomaNormal vs. CancertissueUp18571811
ENSP00000269122Hepatocellular CarcinomaMetastasiscell lineUp1.619016532
ENSP00000269122Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineUp1.618973835
ENSP00000269122Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineUp1.318973835
ENSP00000269122Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineUp1.619714814

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y899ClathrinRFLRENPyYDSRVVGcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANCLH1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04142Lysosome
hsa04144Endocytosis
hsa04721Synaptic vesicle cycle
hsa04961Endocrine and other factor-regulated calcium reabs
hsa05100Bacterial invasion of epithelial cells
hsa05016Huntington's disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007411axon guidanceTASbiological_process
GO:0005488bindingIEAmolecular_function
GO:0016044cellular membrane organizationTASbiological_process
GO:0030669clathrin-coated endocytic vesicle membraneTAScellular_component
GO:0030117membrane coatIEAcellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0033572transferrin transportIMPbiological_process
GO:0030130clathrin coat of trans-Golgi network vesicleIEAcellular_component
GO:0006898receptor-mediated endocytosisIMPbiological_process
GO:0032588trans-Golgi network membraneTAScellular_component
GO:0030132clathrin coat of coated pitIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0007067mitosisIMPbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0042470melanosomeIEAcellular_component
GO:0006886intracellular protein transportNASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0016192vesicle-mediated transportIEAbiological_process
GO:0019886antigen processing and presentation of exogenous pTASbiological_process
GO:0042059negative regulation of epidermal growth factor recTASbiological_process
GO:0005819spindleIDAcellular_component
GO:0030136clathrin-coated vesicleIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0030118clathrin coatNAScellular_component
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0031623receptor internalizationIMPbiological_process
GO:0006892post-Golgi vesicle-mediated transportTASbiological_process
GO:0005198structural molecule activityNASmolecular_function


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