Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CHD8_HUMAN
Description:chromodomain helicase DNA binding protein 8 [Source:HGNC Symbol;Acc:20153]
Location:chr14 q11.2
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S2071EDDSDsELDLSBRKPhosphoSitePlus
T535KSKLNtITPVVSNF2_NPhosphoSitePlus
T1772SPSDTtPLVSRHPRD
S2182PSSRRsQEMVTPhosphoSitePlus
S1432DERPRsRRHDRPhosphoSitePlus
S1044EDDEGsKFCEEHPRD
S409PQAGSsQGASSChromoPhosphoSitePlus
S1424FSDLEsEDDERPhosphoSitePlus
S1903PSSRRsQEMVTHPRD
Y2516LRAPGyPSSPVPhosphoSitePlus
S1978PAPSLsRCSTPPhosphoSitePlus
T1475FKRRMtERDVEPhosphoSitePlus
T1993QYTSRtASPLPPhosphoSitePlus
T278VTLTStPTQGEPhosphoSitePlus
S1699PAPSLsRCSTPHPRD; SysPTM
S2069EDEDDsDSELDBRKPhosphoSitePlus
S1716TSRTAsPLPLRHPRD; SysPTM
S2085PSSSSsSSSSSPhosphoSitePlus
Y1989LLHQQyTSRTAPhosphoSitePlus
T258KLNTItPVVGKHPRD; phosphoELM; SysPTM
S252KTKGKsKLNTIHPRD
S2046YEMRVsPSDTTBRKPhosphoSitePlus
S2518APGYPsSPVTTPhosphoSitePlus
T527SGASKtKGKSKPhosphoSitePlus
S1792EDDSDsELDLSHPRD
S2083LSPSSsSSSSSPhosphoSitePlus
T1714QYTSRtASPLPHPRD
T2215DSPVPtPRSSSPhosphoSitePlus
T1982LSRCStPLLHQPhosphoSitePlus
S1797SELDLsKLSPSHPRD
S2556SQGYDsSERDFPhosphoSitePlus
T1131TRHFStLKDDDHPRD; SysPTM
S2126LSLTMsQDGFPBRKPhosphoSitePlus
S549RKRNTsSDNSDSNF2_NPhosphoSitePlus
S270RKRNTsSDNSDHPRD
S2551DDDDLsQGYDSPhosphoSitePlus
S274TSSDNsDVEVMHPRD
S283VMPAQsPREDEHPRD
S1679VLDNFsDIVEGPhosphoSitePlus
T256KSKLNtITPVVHPRD
S1842KKTDEsLTKYFPhosphoSitePlus
S1729APVEKsPEETAHPRD
S2239APGYPsSPVTTHPRD
T537KLNTItPVVGKSNF2_NPhosphoSitePlus
S271KRNTSsDNSDVHPRD
S1141DLVEFsDLESEHPRD; phosphoELM
S2200NHLLDsPSLTPPhosphoSitePlus
S1790EDEDDsDSELDHPRD
S550KRNTSsDNSDVSNF2_NPhosphoSitePlus
S1697GAPAPsLSRCSHPRD; SysPTM
T1990LHQQYtSRTASPhosphoSitePlus
S1995TSRTAsPLPLRPhosphoSitePlus
S277AVTLTsTPTQGPhosphoSitePlus
T1119NLVIDtPRVRKphosphoELM; SysPTM
S2519PGYPSsPVTTAPhosphoSitePlus
S1145FSDLEsEDDERHPRD; phosphoELM
S562VMPAQsPREDESNF2_NPhosphoSitePlus
S1976GAPAPsLSRCSPhosphoSitePlus
T1733KSPEEtATQVPHPRD
S153VAALSsPASSAHPRD
T209KVLTGtPLRPGPhosphoSitePlus
T2204DSPSLtPGEYGPhosphoSitePlus
S531KTKGKsKLNTIPhosphoSitePlus
S2525PVTTAsGTTLRPhosphoSitePlus
T2012KSPEEtATQVPPhosphoSitePlus
T2051SPSDTtPLVSRBRKPhosphoSitePlus
T2014PEETAtQVPSLPhosphoSitePlus
S2277SQGYDsSERDFHPRD
S2202LLDSPsLTPGEPhosphoSitePlus
S2086SSSSSsSSSSSPhosphoSitePlus
S553TSSDNsDVEVMSNF2_NPhosphoSitePlus
S2240PGYPSsPVTTAHPRD; SysPTM
S2084SPSSSsSSSSSPhosphoSitePlus
S1991HQQYTsRTASPPhosphoSitePlus
S2211GEYGDsPVPTPPhosphoSitePlus
S1466WRDILsHGRFKPhosphoSitePlus
T207FTKVLtGTPLRPhosphoSitePlus
T248SGASKtKGKSKHPRD
T548KRKRNtSSDNSSNF2_NPhosphoSitePlus
S2272DDDDLsQGYDSHPRD
T269KRKRNtSSDNSHPRD
S1632SEADKsLLIGVPhosphoSitePlus
T1398NLVIDtPRVRKPhosphoSitePlus
S1420DLVEFsDLESEPhosphoSitePlus
S1981SLSRCsTPLLHPhosphoSitePlus
S161SSAPHsGGKTGHPRD
S1767YEMRVsPSDTTHPRD; SysPTM
S2008APVEKsPEETAPhosphoSitePlus
S432VAALSsPASSAPhosphoSitePlus

Dephosphorylation site
CHD8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000406288A245TBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000382863R475HBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000406288M1683IBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
CHD8_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CHD8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CHD8_HUMANCTNB1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04310Wnt signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0071339MLL1 complexIDAcellular_component
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0060070canonical Wnt receptor signaling pathwayIEAbiological_process
GO:0070016armadillo repeat domain bindingIEAmolecular_function
GO:0043044ATP-dependent chromatin remodelingIMPbiological_process
GO:0030178negative regulation of Wnt receptor signaling pathIEAbiological_process
GO:0016817hydrolase activity, acting on acid anhydridesIEAmolecular_function
GO:0042393histone bindingISSmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0032508DNA duplex unwindingIMPbiological_process
GO:0042393histone bindingIEAmolecular_function
GO:0035064methylated histone residue bindingIDAmolecular_function
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0002039p53 bindingISSmolecular_function
GO:0043234protein complexIEAcellular_component
GO:0043234protein complexIDAcellular_component
GO:0003677DNA bindingIMPmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004386helicase activityIEAmolecular_function
GO:0008013beta-catenin bindingIDAmolecular_function
GO:0008013beta-catenin bindingIEAmolecular_function
GO:0016787hydrolase activityIEAmolecular_function
GO:0003678DNA helicase activityIMPmolecular_function
GO:0008094DNA-dependent ATPase activityIDAmolecular_function
GO:0045945positive regulation of transcription from RNA polyIMPbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0002039p53 bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0030178negative regulation of Wnt receptor signaling pathIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0060070canonical Wnt receptor signaling pathwayIDAbiological_process


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