Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CENPA_HUMAN
Description:centromere protein A [Source:HGNC Symbol;Acc:1851]
Location:chr2 p23.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S17APRRRsPSPTPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S7GPRRRsRKPEAAurA(STK6RegPhos
S7GPRRRsRKPEAAurB(STK12RegPhos
S7KPEAphosphoELM
S7KPEAAURKBHPRD
S7GPRRRsRKPEAAurARegPhos
S7KPEAAurora AphosphoELM
S7KPEAAurora BphosphoELM
T23PSPTPtPGPSRHPRD; phosphoELM
S7GPRRRsRKPEAPhosphoSitePlus
S27PTPGPsRRGPSPhosphoSitePlus; HPRD; phosphoELM
S7GPRRRsRKPEAAurB(Aurora BRegPhos
S7GPRRRsRKPEAAurBRegPhos
S19RRRSPsPTPTPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T21RSPSPtPTPGPPhosphoSitePlus; HPRD

Dephosphorylation site
CENPA_HUMAN do not have dephosphorylation site.

Mutation site
CENPA_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000336868breast ductal carcinomaNormal vs. CancertissueUp18564057

Hyperphosphorylation site
CENPA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AURKB_HUMANCENPA_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANCENPA_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
CENPA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolTAScellular_component
GO:0034080CENP-A containing nucleosome assembly at centromerTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0000786nucleosomeIEAcellular_component
GO:0000780condensed nuclear chromosome, centromeric regionIDAcellular_component
GO:0006334nucleosome assemblyTASbiological_process
GO:0051382kinetochore assemblyIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0003682chromatin bindingTASmolecular_function
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0000236mitotic prometaphaseTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0000778condensed nuclear chromosome kinetochoreIDAcellular_component
GO:0005634nucleusTAScellular_component
GO:0000132establishment of mitotic spindle orientationIMPbiological_process
GO:0000939condensed chromosome inner kinetochoreIEAcellular_component
GO:0000775chromosome, centromeric regionIDAcellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0071459protein localization to chromosome, centromeric reIDAbiological_process
GO:0000087M phase of mitotic cell cycleTASbiological_process


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