| UniProt/SwissProt ID: | CENPA_HUMAN |
| Description: | centromere protein A [Source:HGNC Symbol;Acc:1851] |
| Location: | chr2 p23.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S17 | APRRRsPSPTP | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S7 | GPRRRsRKPEA | AurA(STK6 | RegPhos |
| S7 | GPRRRsRKPEA | AurB(STK12 | RegPhos |
| S7 | KPEA | phosphoELM | |
| S7 | KPEA | AURKB | HPRD |
| S7 | GPRRRsRKPEA | AurA | RegPhos |
| S7 | KPEA | Aurora A | phosphoELM |
| S7 | KPEA | Aurora B | phosphoELM |
| T23 | PSPTPtPGPSR | HPRD; phosphoELM | |
| S7 | GPRRRsRKPEA | PhosphoSitePlus | |
| S27 | PTPGPsRRGPS | PhosphoSitePlus; HPRD; phosphoELM | |
| S7 | GPRRRsRKPEA | AurB(Aurora B | RegPhos |
| S7 | GPRRRsRKPEA | AurB | RegPhos |
| S19 | RRRSPsPTPTP | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| T21 | RSPSPtPTPGP | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| CENPA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| CENPA_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000336868 | breast ductal carcinoma | Normal vs. Cancer | tissue | Up | 18564057 | |
| Hyperphosphorylation site |
| CENPA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AURKB_HUMAN | CENPA_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| ZAGL2_HUMAN | CENPA_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| CENPA_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0034080 | CENP-A containing nucleosome assembly at centromer | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0000786 | nucleosome | IEA | cellular_component |
| GO:0000780 | condensed nuclear chromosome, centromeric region | IDA | cellular_component |
| GO:0006334 | nucleosome assembly | TAS | biological_process |
| GO:0051382 | kinetochore assembly | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0003682 | chromatin binding | TAS | molecular_function |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0000236 | mitotic prometaphase | TAS | biological_process |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0000778 | condensed nuclear chromosome kinetochore | IDA | cellular_component |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0000132 | establishment of mitotic spindle orientation | IMP | biological_process |
| GO:0000939 | condensed chromosome inner kinetochore | IEA | cellular_component |
| GO:0000775 | chromosome, centromeric region | IDA | cellular_component |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0071459 | protein localization to chromosome, centromeric re | IDA | biological_process |
| GO:0000087 | M phase of mitotic cell cycle | TAS | biological_process |