| UniProt/SwissProt ID: | CDK8_HUMAN |
| Description: | cyclin-dependent kinase 8 [Source:HGNC Symbol;Acc:1779] |
| Location: | chr13 q12.13 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S130 | RGMVKsLLYQI | Pkinase | PhosphoSitePlus |
| S80 | HPNVIsLQKVF | Pkinase | PhosphoSitePlus |
| S11 | KVKLSsERERV | PhosphoSitePlus | |
| S413 | PPTTTsGGLIM | PhosphoSitePlus | |
| Y133 | VKSLLyQILDG | Pkinase | PhosphoSitePlus |
| Y141 | LDGIHyLHANW | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| CDK8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000370938 | E165Q | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000370938 | R424C | HPI | Colorectal Cancer | 17344846 | ENSP00000370938 | D189N | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 | ENSP00000370938 | R424C | Greenman2007 | Intestines Cancer | 17344846, 18428421 |
| Differential expressed protein |
| CDK8_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CDK8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK8_HUMAN | CCNH_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| CDK8_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0004693 | cyclin-dependent protein kinase activity | IEA | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0007179 | transforming growth factor beta receptor signaling | TAS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0006367 | transcription initiation from RNA polymerase II pr | TAS | biological_process |
| GO:0004672 | protein kinase activity | TAS | molecular_function |
| GO:0045944 | positive regulation of transcription from RNA poly | TAS | biological_process |
| GO:0016592 | mediator complex | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008353 | RNA polymerase II carboxy-terminal domain kinase a | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |