Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCNH_HUMAN
Description:cyclin H [Source:HGNC Symbol;Acc:1594]
Location:chr5 q14.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y297KKRKGyEDDDYPhosphoSitePlus
S304DDDYVsKKSKHCDK8HPRD; RegPhos
S304DDDYVsKKSKHPhosphoSitePlus
S5MYHNSsQKRHCDK8RegPhos
S132GNLREsPLGQEHPRD; SysPTM
S322DDLVEHPRD; phosphoELM; SysPTM
S132GNLREsPLGQECyclin_NPhosphoSitePlus; SysPTM
T315EEEEWtDDDLVCK2_groupphosphoELM; RegPhos; SysPTM
S307YVSKKsKHEEEPhosphoSitePlus; HPRD; SysPTM
S5QKRHCDK8HPRD
S322DDLVEsL____PhosphoSitePlus; SysPTM
T315EEEEWtDDDLVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S233MESYLsESLMLHPRD
T227SRAGItMESYLHPRD
S5_MYHNsSQKRHPhosphoSitePlus
Y302YEDDDyVSKKSPhosphoSitePlus
Y262NLVKKyEPPRSCyclin_CPhosphoSitePlus

Dephosphorylation site
CCNH_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000256897D299VCOSMICRenal Cancer20054297
ENSP00000256897D317ECOSMICOvarian Cancer21720365

Differential expressed protein
CCNH_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CCNH_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK8_HUMANCCNH_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANCCNH_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04110Cell cycle
hsa03022Basal transcription factors
hsa03420Nucleotide excision repair

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016032viral reproductionTASbiological_process
GO:0000718nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0008094DNA-dependent ATPase activityIDAmolecular_function
GO:0008353RNA polymerase II carboxy-terminal domain kinase aIDAmolecular_function
GO:0006362transcription elongation from RNA polymerase I proTASbiological_process
GO:0006363termination of RNA polymerase I transcriptionTASbiological_process
GO:0070985TFIIK complexIEAcellular_component
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0016591DNA-directed RNA polymerase II, holoenzymeIEAcellular_component
GO:0000080G1 phase of mitotic cell cycleTASbiological_process
GO:0000079regulation of cyclin-dependent protein kinase actiIEAbiological_process
GO:0006283transcription-coupled nucleotide-excision repairTASbiological_process
GO:0006360transcription from RNA polymerase I promoterTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0006366transcription from RNA polymerase II promoterIDAbiological_process
GO:0016301kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:00063707-methylguanosine mRNA cappingTASbiological_process
GO:0006368transcription elongation from RNA polymerase II prTASbiological_process
GO:0006281DNA repairTASbiological_process
GO:0050434positive regulation of viral transcriptionTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0006361transcription initiation from RNA polymerase I proTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0006289nucleotide-excision repairTASbiological_process
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0051726regulation of cell cycleIEAbiological_process
GO:0005675holo TFIIH complexIEAcellular_component
GO:0005634nucleusTAScellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0019907cyclin-dependent protein kinase activating kinase IDAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0016538cyclin-dependent protein kinase regulator activityIEAmolecular_function