| UniProt/SwissProt ID: | CDK15_HUMAN |
| Description: | cyclin-dependent kinase 15 [Source:HGNC Symbol;Acc:14434] |
| Location: | chr2 q33.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y118 | SYATVyKGISR | Pkinase | PhosphoSitePlus |
| Y63 | LGEGSyATVYK | HPRD | |
| Y114 | LGEGSyATVYK | Pkinase | PhosphoSitePlus |
| Y67 | SYATVyKGISR | HPRD | |
| Dephosphorylation site |
| CDK15_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000386901 | V210M | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000386901 | E225D | Greenman2007 | Breast Cancer | 17344846 | ENSP00000260967 | F243L | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000386901 | K42E | Greenman2007 | Renal Cancer | 17344846 | ENSP00000260967 | V210M | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000260967 | K42E | Greenman2007 | Renal Cancer | 17344846 | ENSP00000260967 | E225D | Greenman2007 | Breast Cancer | 17344846 |
| Differential expressed protein |
| CDK15_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CDK15_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK15_HUMAN | CBL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| CDK15_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0004693 | cyclin-dependent protein kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |