| UniProt/SwissProt ID: | CD70_HUMAN |
| Description: | CD70 molecule [Source:HGNC Symbol;Acc:11937] |
| Location: | chr19 p13.3 |
| Node attribute: | ligand; PPI(source) |
| Phosphorylation site |
| CD70_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| CD70_HUMAN do not have dephosphorylation site. |
| Mutation site |
| CD70_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000245903 | Ovarian Cancer | Treatment (cisplatin-sensitive vs. cisplatin-resistant) | cell line | Up | 18 | 19800108 |
| Hyperphosphorylation site |
| CD70_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CD70_HUMAN | CD27_HUMAN | ligand -> receptor | HPMR |
| CD70_HUMAN | CD27_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0006917 | induction of apoptosis | IDA | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005102 | receptor binding | TAS | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0006955 | immune response | IEA | biological_process |
| GO:0005125 | cytokine activity | IEA | molecular_function |
| GO:0002020 | protease binding | IPI | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005164 | tumor necrosis factor receptor binding | IEA | molecular_function |
| GO:0007267 | cell-cell signaling | TAS | biological_process |