| UniProt/SwissProt ID: | CD20_HUMAN |
| Description: | membrane-spanning 4-domains, subfamily A, member 1 [Source:HGNC Symbol;Acc:7315] |
| Location: | chr11 q12.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T250 | EVVGLtETSSQ | CSNK2A1 | HPRD |
| T250 | EVVGLtETSSQ | CSNK2A2 | HPRD |
| S35 | LFRRMsSLVGP | PhosphoSitePlus | |
| T11 | NSVNGtFPAEP | PhosphoSitePlus | |
| S231 | NIVLLsAEEKK | CK2a1 | RegPhos |
| T250 | EVVGLtETSSQ | CK2a2 | RegPhos |
| T2 | ____MtTPRNS | PhosphoSitePlus | |
| S289 | QDQESsPIEND | CK2_group | phosphoELM; RegPhos |
| S231 | NIVLLsAEEKK | CK2a2 | RegPhos |
| S289 | QDQESsPIEND | CK2a2 | RegPhos |
| S231 | NIVLLsAEEKK | CK2_group | phosphoELM; RegPhos |
| S253 | GLTETsSQPKN | PhosphoSitePlus | |
| S289 | QDQESsPIEND | CK2a1-rs | RegPhos |
| S289 | QDQESsPIEND | CSNK2A1 | HPRD |
| S289 | QDQESsPIEND | CSNK2A2 | HPRD |
| T250 | EVVGLtETSSQ | CK2a1 | RegPhos |
| S36 | FRRMSsLVGPT | PhosphoSitePlus | |
| S289 | QDQESsPIEND | CK2a1 | RegPhos |
| T250 | EVVGLtETSSQ | CK2_group | phosphoELM; RegPhos |
| T250 | EVVGLtETSSQ | CK2a1-rs | RegPhos |
| S225 | CSRPKsNIVLL | PhosphoSitePlus | |
| S7 | TTPRNsVNGTF | PhosphoSitePlus | |
| T3 | ___MTtPRNSV | PhosphoSitePlus | |
| T250 | EVVGLtETSSQ | PhosphoSitePlus | |
| S254 | LTETSsQPKNE | PhosphoSitePlus | |
| S231 | NIVLLsAEEKK | PhosphoSitePlus | |
| S121 | KMIMNsLSLFA | CD20; TM | PhosphoSitePlus |
| S231 | NIVLLsAEEKK | CSNK2A2 | HPRD |
| S231 | NIVLLsAEEKK | CSNK2A1 | HPRD |
| S231 | NIVLLsAEEKK | CK2a1-rs | RegPhos |
| Dephosphorylation site |
| CD20_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000314620 | T2K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000374589 | G68V | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000374589 | T2K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000374589 | T2K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000374589 | G91S | COSMIC | Lung Cancer | 20668451 | ENSP00000433277 | G68V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000374589 | S179Y | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000374589 | M46I | COSMIC | Lung Cancer | 20668451 | ENSP00000314620 | G68V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000433277 | T2K | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| CD20_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CD20_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK22_HUMAN | CD20_HUMAN | kinase -> substrate | HPRD |
| CSK21_HUMAN | CD20_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04640 | Hematopoietic cell lineage |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0042113 | B cell activation | IEA | biological_process |
| GO:0006955 | immune response | TAS | biological_process |