Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCR7_HUMAN
Description:chemokine (C-C motif) receptor 7 [Source:HGNC Symbol;Acc:1608]
Location:chr17 q21.2
Node attribute:receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T373VEAETtTTFSPPhosphoSitePlus
Y65FLPIMySIICFTMPhosphoSitePlus
S364RHIRRsSMSVEPhosphoSitePlus
S151LLLCIsIDRYVTM; 7tm_1PhosphoSitePlus
S377TTTTFsP____PhosphoSitePlus
S356QLRQWsSCRHIPhosphoSitePlus
T375AETTTtFSP__PhosphoSitePlus
T372SVEAEtTTTFSPhosphoSitePlus
T374EAETTtTFSP_PhosphoSitePlus
S365HIRRSsMSVEAPhosphoSitePlus
S357LRQWSsCRHIRPhosphoSitePlus
S66LPIMYsIICFVTMPhosphoSitePlus

Dephosphorylation site
CCR7_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000246657E193KCOSMICHead and Neck Cancer21984974

Differential expressed protein
CCR7_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CCR7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CCL21_HUMANCCR7_HUMANligand -> receptorHPMR
CCL19_HUMANCCR7_HUMANligand -> receptorHPMR
CCL21_HUMANCCR7_HUMANotherKEGG
CCL19_HUMANCCR7_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa05202Transcriptional misregulation in cancer
hsa04062Chemokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:2000107negative regulation of leukocyte apoptotic processICbiological_process
GO:0051209release of sequestered calcium ion into cytosolICbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0002885positive regulation of hypersensitivityIEAbiological_process
GO:0038116chemokine (C-C motif) ligand 21 signaling pathwayIDAbiological_process
GO:2000525positive regulation of T cell costimulationIEAbiological_process
GO:0030838positive regulation of actin filament polymerizatiICbiological_process
GO:2000526positive regulation of glycoprotein biosynthetic pIEAbiological_process
GO:0043552positive regulation of phosphatidylinositol 3-kinaICbiological_process
GO:0046330positive regulation of JNK cascadeICbiological_process
GO:0035757chemokine (C-C motif) ligand 19 bindingIPImolecular_function
GO:0051897positive regulation of protein kinase B signaling ICbiological_process
GO:0002922positive regulation of humoral immune responseIEAbiological_process
GO:0006954inflammatory responseNASbiological_process
GO:0004930G-protein coupled receptor activityTASmolecular_function
GO:0002606positive regulation of dendritic cell antigen procIEAbiological_process
GO:0090023positive regulation of neutrophil chemotaxisIEAbiological_process
GO:0032649regulation of interferon-gamma productionIEAbiological_process
GO:0034695response to prostaglandin E stimulusICbiological_process
GO:0031529ruffle organizationICbiological_process
GO:0002407dendritic cell chemotaxisICbiological_process
GO:2000147positive regulation of cell motilityICbiological_process
GO:0001768establishment of T cell polarityICbiological_process
GO:0016493C-C chemokine receptor activityIEAmolecular_function
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0032735positive regulation of interleukin-12 productionIEAbiological_process
GO:0002408myeloid dendritic cell chemotaxisICbiological_process
GO:0005622intracellularIEAcellular_component
GO:0051491positive regulation of filopodium assemblyICbiological_process
GO:0071731response to nitric oxideICbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeICbiological_process
GO:0045060negative thymic T cell selectionIEAbiological_process
GO:0031274positive regulation of pseudopodium assemblyICbiological_process
GO:2000547regulation of dendritic cell dendrite assemblyISSbiological_process
GO:0006955immune responseIEAbiological_process
GO:2000522positive regulation of immunological synapse formaIEAbiological_process
GO:0097022lymphocyte migration into lymph nodeTASbiological_process
GO:0006935chemotaxisIEAbiological_process
GO:0032862activation of Rho GTPase activityICbiological_process
GO:2000510positive regulation of dendritic cell chemotaxisIEAbiological_process
GO:0050706regulation of interleukin-1 beta secretionIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0001954positive regulation of cell-matrix adhesionICbiological_process
GO:0038115chemokine (C-C motif) ligand 19 signaling pathwayIDAbiological_process
GO:0097029mature dendritic cell differentiationIEAbiological_process
GO:0045785positive regulation of cell adhesionICbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cICbiological_process
GO:0072610interleukin-12 secretionIEAbiological_process
GO:0038117C-C motif chemokine 19 receptor activityIDAmolecular_function
GO:0038121C-C motif chemokine 21 receptor activityIDAmolecular_function
GO:0035758chemokine (C-C motif) ligand 21 bindingIPImolecular_function
GO:0045860positive regulation of protein kinase activityICbiological_process
GO:0050862positive regulation of T cell receptor signaling pIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0007204elevation of cytosolic calcium ion concentrationTASbiological_process