| UniProt/SwissProt ID: | CBX1_HUMAN |
| Description: | chromobox homolog 1 [Source:HGNC Symbol;Acc:1551] |
| Location: | chr17 q21.32 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S91 | KADSDsEDKGE | PhosphoSitePlus; HPRD | |
| Y173 | LTWHSyPSEDD | PhosphoSitePlus | |
| S80 | HETDKsEGGKR | PhosphoSitePlus | |
| S89 | KRKADsDSEDK | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T73 | LQSQKtAHETD | PhosphoSitePlus | |
| T77 | KTAHEtDKSEG | PhosphoSitePlus | |
| S70 | AEFLQsQKTAH | Chromo | PhosphoSitePlus |
| S175 | WHSYPsEDDDK | PhosphoSitePlus; HPRD | |
| T51 | SDEDNtWEPEE | Chromo | PhosphoSitePlus |
| S128 | IGATDsSGELM | Chromo_shadow | PhosphoSitePlus |
| S172 | RLTWHsYPSED | Chromo_shadow | PhosphoSitePlus |
| Dephosphorylation site |
| CBX1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| CBX1_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000377060 | Prostate Cancer | Metastasis | tissue | Up | 3.4 | 18553995 |
| Hyperphosphorylation site |
| CBX1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DYRK2_HUMAN | CBX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| CBX1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042802 | identical protein binding | IEA | molecular_function |
| GO:0000785 | chromatin | IDA | cellular_component |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0010369 | chromocenter | IEA | cellular_component |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0001940 | male pronucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:0005721 | centromeric heterochromatin | IEA | cellular_component |
| GO:0000775 | chromosome, centromeric region | IDA | cellular_component |
| GO:0000785 | chromatin | IEA | cellular_component |
| GO:0005720 | nuclear heterochromatin | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0003682 | chromatin binding | TAS | molecular_function |
| GO:0001939 | female pronucleus | IEA | cellular_component |
| GO:0005819 | spindle | IDA | cellular_component |