Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CASQ2_HUMAN
Description:calsequestrin 2 (cardiac muscle) [Source:HGNC Symbol;Acc:1513]
Location:chr1 p13.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S385DDDDNsDEEDNCSNK2A2HPRD
Y178SEDSEyYKAFECalsequestrinPhosphoSitePlus
S385DDDDNsDEEDNPhosphoSitePlus
S176FKSEDsEYYKACalsequestrinPhosphoSitePlus
Y179EDSEYyKAFEECalsequestrinPhosphoSitePlus
S385DDDDNsDEEDNCSNK2A1HPRD
S302DNPDLsILWIDHPRD; phosphoELM
S393EDNDDsDDDDDPhosphoSitePlus
Y282SDPDGyEFLEICalsequestrinPhosphoSitePlus

Dephosphorylation site
CASQ2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261448D32NCOSMICMelanoma21499247

Differential expressed protein
CASQ2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CASQ2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK22_HUMANCASQ2_HUMANkinase -> substrateHPRD
CSK21_HUMANCASQ2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
CASQ2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0010649regulation of cell communication by electrical couIMPbiological_process
GO:0014701junctional sarcoplasmic reticulum membraneTAScellular_component
GO:0071313cellular response to caffeineIMPbiological_process
GO:1901017negative regulation of potassium ion transmembraneIEAbiological_process
GO:0051208sequestering of calcium ionIDAbiological_process
GO:0043267negative regulation of potassium ion transportIEAbiological_process
GO:0002027regulation of heart rateIMPbiological_process
GO:0010881regulation of cardiac muscle contraction by regulaIEAbiological_process
GO:0016529sarcoplasmic reticulumISScellular_component
GO:0060306regulation of membrane repolarizationISSbiological_process
GO:0005891voltage-gated calcium channel complexISScellular_component
GO:0043267negative regulation of potassium ion transportISSbiological_process
GO:0033018sarcoplasmic reticulum lumenICcellular_component
GO:0006941striated muscle contractionTASbiological_process
GO:0060315negative regulation of ryanodine-sensitive calciumISSbiological_process
GO:1901017negative regulation of potassium ion transmembraneISSbiological_process
GO:0060306regulation of membrane repolarizationIEAbiological_process
GO:0030018Z discISScellular_component
GO:0042803protein homodimerization activityISSmolecular_function
GO:0010880regulation of release of sequestered calcium ion iISSbiological_process
GO:0005622intracellularIMPcellular_component
GO:0005509calcium ion bindingIDAmolecular_function
GO:0010881regulation of cardiac muscle contraction by regulaIMPbiological_process
GO:0086029Purkinje myocyte to ventricular cardiac muscle celNASbiological_process
GO:0030018Z discIEAcellular_component


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