Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CAR11_HUMAN
Description:caspase recruitment domain family, member 11 [Source:HGNC Symbol;Acc:16393]
Location:chr7 p22.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y489PEDSKyFLPYHPhosphoSitePlus
S925RIISGsPLGSLPhosphoSitePlus
S995QRLLNsGGAMEPhosphoSitePlus
S487ESPEDsKYFLPPhosphoSitePlus
T117TRRFStIVVEEPhosphoSitePlus
T532HEEEGtDASPSPhosphoSitePlus
T864DGTHHtLRALRPhosphoSitePlus
Y11PEMDDyMETLKPhosphoSitePlus
S433IVNLEsKLRRLPhosphoSitePlus
Y202VKDDNyNLAMRPhosphoSitePlus
Y970LVRAFyCERRRPhosphoSitePlus
T1002GAMEFtICKSDPhosphoSitePlus
S538DASPSsCGSLPPhosphoSitePlus
S556MQPPRsRSSIMPhosphoSitePlus
S512LQRAKsPISLKPhosphoSitePlus
T871RALRNtLQPEEPhosphoSitePlus
Y493KYFLPyHPPQRPhosphoSitePlus
S558PPRSRsSIMSIPhosphoSitePlus
S615SFGPSsIHSSSPhosphoSitePlus
S547LPITNsFTKMQPhosphoSitePlus
S559PRSRSsIMSITPhosphoSitePlus
Y208NLAMRyAQLSEPhosphoSitePlus
S562RSSIMsITAEPPhosphoSitePlus
S466DFGDAsPRTNGPhosphoSitePlus
S459PVTIIsQDFGDPhosphoSitePlus
T549ITNSFtKMQPPPhosphoSitePlus
S448NNLDQsLPRNLPhosphoSitePlus
S116PTRRFsTIVVEPhosphoSitePlus
S541PSSCGsLPITNPhosphoSitePlus
S886SDPRVsPRLSRPhosphoSitePlus
S593EEDNDsGGFDAPhosphoSitePlus
S572PPGNDsIVRRYPhosphoSitePlus

Dephosphorylation site
CAR11_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000380150D632NBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
CAR11_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CAR11_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCB_HUMANCAR11_HUMANkinase -> substrateKEGG; NetPath
M4K1_HUMANCAR11_HUMANkinase -> substrateNetPath
KPCT_HUMANCAR11_HUMANkinase -> substrateKEGG; NetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04660T cell receptor signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04662B cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050870positive regulation of T cell activationIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0001819positive regulation of cytokine productionIMPbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0042102positive regulation of T cell proliferationIEAbiological_process
GO:0042101T cell receptor complexIDAcellular_component
GO:0045577regulation of B cell differentiationIEAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0045121membrane raftIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0030890positive regulation of B cell proliferationIEAbiological_process
GO:0045086positive regulation of interleukin-2 biosynthetic IEAbiological_process
GO:0045061thymic T cell selectionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0045580regulation of T cell differentiationIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0050700CARD domain bindingIPImolecular_function
GO:0051092positive regulation of NF-kappaB transcription facIMPbiological_process
GO:0050776regulation of immune responseIEAbiological_process
GO:0004385guanylate kinase activityNASmolecular_function
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0031295T cell costimulationIDAbiological_process


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