Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CALR_HUMAN
Description:calreticulin [Source:HGNC Symbol;Acc:1455]
Location:chr19 p13.2
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y150HVIFNyKGKNVCalreticulinPhosphoSitePlus
Y75QDARFyALSASCalreticulinPhosphoSitePlus
Y109DCGGGyVKLFPCalreticulinPhosphoSitePlus
Y299IDNPEySPDPSCalreticulinPhosphoSitePlus
Y57SSGKFyGDEEKCalreticulinPhosphoSitePlus
S300DNPEYsPDPSICalreticulinPhosphoSitePlus
S52GKFVLsSGKFYCalreticulinPhosphoSitePlus
Y22AEPAVyFKEQFCalreticulinPhosphoSitePlus

Dephosphorylation site
CALR_HUMAN do not have dephosphorylation site.

Mutation site
CALR_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000320866Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000320866colorectal cancerNormal vs. CancertissueDown0.7515924290
ENSP00000320866papillary thyroid carcinomaNormal vs. CancertissueDown0.3316788983
ENSP00000320866Thyroid CarcinomaNormal vs. CancertissueUp3.217194741
ENSP00000320866Prostate CancerMetastasiscell lineUp1.918232632
ENSP00000320866follicular thyroid carcinomaNormal vs. CancertissueDown0.4418316623
ENSP00000320866Breast CancerNormal vs. Cancercell lineDown0.2916596714
ENSP00000320866Breast CancerNormal vs. Cancercell lineDown0.1716596714
ENSP00000320866hepatitis C virusNormal vs. CancertissueDown16762624
ENSP00000320866hepatitis C virusNormal vs. CancertissueUp16762624
ENSP00000320866Hepatocellular CarcinomaNormal vs. CancertissueUp18571811
ENSP00000320866hepatitis B virusTreatment (none vs tetracycline-treatment)cell lineDown0.4519671925
ENSP00000320866Hepatocellular CarcinomaNormal vs. CancertissueDown0.6519956837
ENSP00000320866Hepatocellular CarcinomaMetastasiscell lineUp219016532
ENSP00000320866Lung CancerTreatment(none vs transfected with HPV-16 E7 gene)cell lineDown15684709
ENSP00000320866Gastric CancerTreatment (none vs. 5-fluorouracil treatment)cell lineUp2016900703
ENSP00000320866Breast CancerMetastasiscell lineUp1.418582095
ENSP00000320866Breast CancerMetastasiscell lineUp1.518582095
ENSP00000320866Breast CancerNormal vs. CancertissueUp3.120005186
ENSP00000320866Breast CancerNormal vs. Cancercell lineUp2.220052998
ENSP00000320866Breast CancerNormal vs. Cancercell lineDown0.7420052998
ENSP00000320866Breast CancerMetastasiscell lineDown0.3520052998
ENSP00000320866Breast CancerNormal vs. CancertissueDown0.4420087651
ENSP00000320866breast ductal carcinomaNormal vs. CancertissueUp480020534901
ENSP00000320866Breast CancerNormal vs. CancertissueUp20560667
ENSP00000320866acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.2717655343
ENSP00000320866acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.0717655343
ENSP00000320866acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.1417655343
ENSP00000320866acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.1617655343
ENSP00000320866acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown17655343
ENSP00000320866acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000320866Renal CancerNormal vs. CancertissueUp19164279
ENSP00000320866Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.520625496
ENSP00000320866Esophageal CancerNormal vs. CancertissueUp2.416400690

Hyperphosphorylation site
CALR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CALR_HUMANSREC_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04141Protein processing in endoplasmic reticulum
hsa05166HTLV-I infection
hsa04145Phagosome
hsa04612Antigen processing and presentation
hsa05142Chagas disease (American trypanosomiasis)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051208sequestering of calcium ionTASbiological_process
GO:0001669acrosomal vesicleIEAcellular_component
GO:0033018sarcoplasmic reticulum lumenIEAcellular_component
GO:0005509calcium ion bindingISSmolecular_function
GO:0071556integral to lumenal side of endoplasmic reticulum TAScellular_component
GO:0002474antigen processing and presentation of peptide antTASbiological_process
GO:0005844polysomeISScellular_component
GO:0005622intracellularTAScellular_component
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0042824MHC class I peptide loading complexISScellular_component
GO:0071310cellular response to organic substanceIEAbiological_process
GO:0017148negative regulation of translationTASbiological_process
GO:0002502peptide antigen assembly with MHC class I protein ISSbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005844polysomeIEAcellular_component
GO:0005783endoplasmic reticulumTAScellular_component
GO:0007050cell cycle arrestIGIbiological_process
GO:0005178integrin bindingIPImolecular_function
GO:0030246carbohydrate bindingTASmolecular_function
GO:0045665negative regulation of neuron differentiationIDAbiological_process
GO:0034504protein localization to nucleusIDAbiological_process
GO:0045787positive regulation of cell cycleIEAbiological_process
GO:0008284positive regulation of cell proliferationIGIbiological_process
GO:0045740positive regulation of DNA replicationIGIbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0050821protein stabilizationISSbiological_process
GO:2000510positive regulation of dendritic cell chemotaxisIMPbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0002502peptide antigen assembly with MHC class I protein IEAbiological_process
GO:0001849complement component C1q bindingTASmolecular_function
GO:0042921glucocorticoid receptor signaling pathwayTASbiological_process
GO:0031012extracellular matrixIEAcellular_component
GO:0003729mRNA bindingIDAmolecular_function
GO:0090398cellular senescenceIGIbiological_process
GO:0009986cell surfaceTAScellular_component
GO:0005829cytosolIDAcellular_component
GO:0006987activation of signaling protein activity involved TASbiological_process
GO:0042981regulation of apoptotic processTASbiological_process
GO:0050766positive regulation of phagocytosisISSbiological_process
GO:0005506iron ion bindingIEAmolecular_function
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0022417protein maturation by protein foldingTASbiological_process
GO:0043687post-translational protein modificationTASbiological_process
GO:0033574response to testosterone stimulusIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:1900026positive regulation of substrate adhesion-dependenIMPbiological_process
GO:0006874cellular calcium ion homeostasisTASbiological_process
GO:0040020regulation of meiosisIEAbiological_process
GO:0005788endoplasmic reticulum lumenIDAcellular_component
GO:0010033response to organic substanceIEAbiological_process
GO:0055007cardiac muscle cell differentiationIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0009986cell surfaceIEAcellular_component
GO:0051082unfolded protein bindingTASmolecular_function
GO:0090398cellular senescenceIEAbiological_process
GO:0002479antigen processing and presentation of exogenous pTASbiological_process
GO:0007283spermatogenesisIEAbiological_process
GO:0006611protein export from nucleusIDAbiological_process
GO:0034504protein localization to nucleusIEAbiological_process
GO:0042277peptide bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0003729mRNA bindingIEAmolecular_function
GO:0042493response to drugIEAbiological_process
GO:0030246carbohydrate bindingIEAmolecular_function
GO:0048387negative regulation of retinoic acid receptor signIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0050821protein stabilizationIEAbiological_process
GO:0045787positive regulation of cell cycleIGIbiological_process
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005794Golgi apparatusIEAcellular_component
GO:0008270zinc ion bindingTASmolecular_function
GO:0042824MHC class I peptide loading complexIEAcellular_component
GO:0050766positive regulation of phagocytosisIEAbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0044183protein binding involved in protein foldingTASmolecular_function
GO:0006355regulation of transcription, DNA-dependentTASbiological_process
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0003677DNA bindingNASmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0042562hormone bindingIEAmolecular_function
GO:0071285cellular response to lithium ionIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0030866cortical actin cytoskeleton organizationIEAbiological_process
GO:0050681androgen receptor bindingIDAmolecular_function
GO:0033144negative regulation of intracellular steroid hormoIDAbiological_process
GO:0018279protein N-linked glycosylation via asparagineTASbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0016529sarcoplasmic reticulumIEAcellular_component
GO:0017148negative regulation of translationIEAbiological_process
GO:0006457protein foldingTASbiological_process
GO:0042590antigen processing and presentation of exogenous pTASbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0051087chaperone bindingTASmolecular_function