Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CALD1_HUMAN
Description:caldesmon 1 [Source:HGNC Symbol;Acc:1441]
Location:chr7 q33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T285RRRGEtESEEFHPRD
S744KVGVSsRINEWCDK1HPRD
S783LWEKQsVDKVTHPRD; RegPhos
Y160SRQERyEIEETCaldesmonPhosphoSitePlus
S283PGGRAsVDTKEHPRD
S535PAPKPsDLRPGHPRD
T496VFSSPtAAGTPHPRD
T527SVDKVtSPTHPRD
S73VNAQNsVPDEECaldesmonPhosphoSitePlus
S257PGGRAsVDTKEHPRD
T638PFKCFtPKGSSCDC2RegPhos
T317RRRGEtESEEFHPRD
S282TENTFsRPGGRHPRD
S524PDGNKsPAPKPHPRD
T735TPNKEtAGLKVCaldesmonPhosphoSitePlus
S423LEQYTsAIEGTHPRD
S759PDGNKsPAPKPCDC2RegPhos; SysPTM
T730PTAAGtPNKETCDC2 RegPhos
Y21LSQIAyQRNDDHPRD
T726VFSSPtAAGTPHPRD; phosphoELM
S744KVGVSsRINEWCDC2(CDK1RegPhos
S468KGNVFsSPTAAHPRD
S232FTEVKsQNGEFHPRD
S202KPKRGsIGENQHPRD; RegPhos
T753EWLTKtPDGNKCDC2 RegPhos
S548RGETEsEEFEKRegPhos
S529PDGNKsPAPKPHPRD
T469PTAAGtPNKETCDK1HPRD
T730PTAAGtPNKETCDC2RegPhos
T730PTAAGtPNKETCDC2(CDK1RegPhos
T83EAKTTtTNTQVCaldesmonPhosphoSitePlus
T500TPNKEtAGLKVHPRD
T638PFKCFtPKGSSphosphoELM
Y172TVTKSyQKNDWCaldesmonPhosphoSitePlus
T84AKTTTtNTQVECaldesmonPhosphoSitePlus
S724GNVFSsPTAAGCDC2RegPhos
S256TENTFsRPGGRHPRD
S462KGNVFsSPTAAHPRD
T638PFKCFtPKGSSCDK1HPRD
S643TPKGSsLKIEEHPRD; phosphoELM; RegPhos
T500PTAAGtPNKETCDK1HPRD
S289PGGRAsVDTKEHPRD
T753EWLTKtPDGNKHPRD; phosphoELM
S744KVGVSsRINEWCDC2RegPhos
S258FTEVKsQNGEFHPRD
S789VDKVTsPTKVErk1(MAPK3RegPhos; SysPTM
S408TPKGSsLKIEEHPRD
T311RRRGEtESEEFHPRD
S488KGNVFsSPTAAHPRD
S724GNVFSsPTAAGCaldesmonPhosphoSitePlus
S17SLAALsQIAYQHPRD
S759PDGNKsPAPKPCDK1HPRD; SysPTM
S12SHGRRsLAALSHPRD
Y27AERIAyQRNDDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S656EFLNKsVQKSSHPRD; phosphoELM; RegPhos; SysPTM
T475PTAAGtPNKETCDK1HPRD
T498EWLTKtPDGNKHPRD
S514KVGVSsRINEWCDK1HPRD
T546RRRGEtESEEFCaldesmonPhosphoSitePlus
S263PGGRAsVDTKEHPRD
T523EWLTKtPDGNKHPRD
T480TPNKEtAGLKVHPRD
S765PAPKPsDLRPGCaldesmonPhosphoSitePlus
S498PDGNKsPAPKPCDK1HPRD
T730PTAAGtPNKETCDK1HPRD
S765PAPKPsDLRPGHPRD; phosphoELM; RegPhos
S724GNVFSsPTAAGphosphoELM; RegPhos
T553SVDKVtSPTHPRD
S528LWEKQsVDKVTHPRD
S744KVGVSsRINEWphosphoELM
S429LEQYTsAIEGTHPRD
S548LWEKQsVDKVTHPRD
T492EWLTKtPDGNKHPRD
S414TPKGSsLKIEEHPRD
S789VDKVTsPTKV_PhosphoSitePlus; SysPTM
T86TTTTNtQVEGDCaldesmonPhosphoSitePlus
T730PTAAGtPNKETCaldesmonPhosphoSitePlus
S483KVGVSsRINEWCDK1HPRD
T791KVTSPtKV___PhosphoSitePlus
T505TPNKEtAGLKVHPRD
S524PDGNKsPAPKPCDK1HPRD
S421EFLNKsVQKSSHPRD
S196KPKRGsIGENQHPRD
S724GNVFSsPTAAGCDK1HPRD
S528VDKVTsPTHPRD
S427EFLNKsVQKSGHPRD
S723KGNVFsSPTAAHPRD; phosphoELM; RegPhos
S395EFLNKsVQKSSHPRD
Y682SRLEQyTSAIECaldesmonPhosphoSitePlus
S489KVGVSsRINEWCDK1HPRD
T471VFSSPtAAGTPHPRD
S494GNVFSsPTAAGCDK1HPRD
S643TPKGSsLKIEECaldesmonPhosphoSitePlus
S684LEQYTsAIEGTCaldesmonPhosphoSitePlus
S789VDKVTsPTMAPK3phosphoELM; SysPTM
S276TENTFsRPGGRHPRD
S518PGGRAsVDTKEHPRD; phosphoELM; RegPhos
S656EFLNKsVQKSSCaldesmonPhosphoSitePlus; SysPTM
T465VFSSPtAAGTPHPRD
S789VDKVTsPTKVCDC2 RegPhos; SysPTM
S529PDGNKsPAPKPCDK1HPRD
T491VFSSPtAAGTPHPRD
S504PDGNKsPAPKPCDK1HPRD
S493FTEVKsQNGEFHPRD
S504PDGNKsPAPKPHPRD
T383PFKCFtPKGSSCDK1HPRD
S759PDGNKsPAPKPCDC2(CDK1RegPhos; SysPTM
T533SVDKVtSPTHPRD
S202KPKRGsIGENQCaldesmonPhosphoSitePlus
S463GNVFSsPTAAGCDK1HPRD
S744KVGVSsRINEWCaldesmonPhosphoSitePlus
S264FTEVKsQNGEFHPRD
T495PTAAGtPNKETCDK1HPRD
T546RRRGEtESEEFHPRD
S759PDGNKsPAPKPCaldesmonPhosphoSitePlus; SysPTM
S498PDGNKsPAPKPHPRD
S7GRRSHPRD
S504PAPKPsDLRPGHPRD
T291RRRGEtESEEFHPRD
S518PGGRAsVDTKECaldesmonPhosphoSitePlus
S469GNVFSsPTAAGCDK1HPRD
S759PDGNKsPAPKPHPRD; phosphoELM; RegPhos; SysPTM
T788SVDKVtSPTHPRD
T518EWLTKtPDGNKHPRD
S522LWEKQsVDKVTHPRD
S388TPKGSsLKIEEHPRD
S684LEQYTsAIEGTHPRD
S510PAPKPsDLRPGHPRD
S534VDKVTsPTHPRD
T409PFKCFtPKGSSCDK1HPRD
T403PFKCFtPKGSSCDK1HPRD
S553LWEKQsVDKVTHPRD
S530PAPKPsDLRPGHPRD
S714VRNIKsMWEKGCaldesmonPhosphoSitePlus
T753EWLTKtPDGNKCaldesmonPhosphoSitePlus
T638PFKCFtPKGSSCDC2(CDK1RegPhos
S789VDKVTsPTHPRD; phosphoELM; SysPTM
S250TENTFsRPGGRHPRD
S454LEQYTsAIEGTHPRD
S449LEQYTsAIEGTHPRD
T474TPNKEtAGLKVHPRD
S511TENTFsRPGGRHPRD; SysPTM
S493KGNVFsSPTAAHPRD
S509KVGVSsRINEWCDK1HPRD
S401EFLNKsVQKSSHPRD
T730PTAAGtPNKETphosphoELM
S493FTEVKsQNGEFCaldesmonPhosphoSitePlus
S559VDKVTsPTHPRD
S724GNVFSsPTAAGCDC2(CDK1RegPhos
S238FTEVKsQNGEFHPRD
S789VDKVTsPTKVRegPhos; SysPTM
S489GNVFSsPTAAGCDK1HPRD
T558SVDKVtSPTHPRD
T726VFSSPtAAGTPCaldesmonPhosphoSitePlus
T377PFKCFtPKGSSCDK1HPRD
S723KGNVFsSPTAACaldesmonPhosphoSitePlus
S382TPKGSsLKIEEHPRD
S554VDKVTsPTHPRD
T735TPNKEtAGLKVHPRD; phosphoELM

Dephosphorylation site
CALD1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354513R521QBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000355000D140YBIOMARTBrain Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000354826Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.3218646787
ENSP00000354826Breast CancerNormal vs. CancertissueDown0.7520739354
ENSP00000354826Breast CancerNormal vs. CancertissueDown0.7520739354
ENSP00000354826Ovarian CancerMetastasiscell lineDown17892554
ENSP00000354826Ovarian CancerMetastasiscell lineDown17892554
ENSP00000354826Pancreatic CancerNormal vs. CancertissueUp215526344

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S789QSVDKVTsPTKV___prostate cancer22197205PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANCALD1_HUMANkinase -> substrateRegPhos
MK03_HUMANCALD1_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANCALD1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04270Vascular smooth muscle contraction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016020membraneIEAcellular_component
GO:0030478actin capIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005856cytoskeletonTAScellular_component
GO:0015629actin cytoskeletonIDAcellular_component
GO:0005516calmodulin bindingIEAmolecular_function
GO:0003779actin bindingIEAmolecular_function
GO:0005523tropomyosin bindingTASmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0017022myosin bindingIEAmolecular_function
GO:0006936muscle contractionTASbiological_process
GO:0006928cellular component movementTASbiological_process
GO:0006936muscle contractionIEAbiological_process
GO:0030016myofibrilIEAcellular_component


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