Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:C5AR_HUMAN
Description:complement component 5a receptor 1 [Source:HGNC Symbol;Acc:1338]
Location:chr19 q13.32
Node attribute:substrate; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S334VRESKsFTRSTPKC_alphaphosphoELM
S317RKSLPsLLRNVPKC_alphaphosphoELM
S314GRLRKsLPSLLPhosphoSitePlus; HPRD; RegPhos
Y11YTTPDyGHYDDPhosphoSitePlus
S314GRLRKsLPSLLPKC_alphaphosphoELM
S338KSFTRsTVDTMPKC_alphaphosphoELM
S332SVVREsKSFTRPKCa(PKC alphaRegPhos
S338KSFTRsTVDTMPKCa(PKC alphaRegPhos
S327VLTEEsVVRESPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y14PDYGHyDDKDTPhosphoSitePlus
S314GRLRKsLPSLLPKCa(PKC alphaRegPhos
S338KSFTRsTVDTMPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S334VRESKsFTRSTPKCa(PKC alphaRegPhos
T324LRNVLtEESVVPhosphoSitePlus
S332SVVREsKSFTRPKC_alphaphosphoELM
S317RKSLPsLLRNVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S317RKSLPsLLRNVPKCa(PKC alphaRegPhos
S334VRESKsFTRSTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S332SVVREsKSFTRPhosphoSitePlus; HPRD; RegPhos

Dephosphorylation site
C5AR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000347197T29ITCGAOvarian Cancer21720365, 18772890
ENSP00000347197L323FCOSMICOvarian Cancer21720365
ENSP00000347197T29ICOSMICOvarian Cancer21720365
ENSP00000347197V190MCOSMICCentral Nervous System Neoplasms18772396
ENSP00000347197L323FTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
C5AR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
C5AR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CO5_HUMANC5AR_HUMANligand -> receptorHPMR
ZAGL2_HUMANC5AR_HUMANkinase -> substrateRegPhos
KPCA_HUMANC5AR_HUMANkinase -> substrateRobert H Newman (2013)
IP3KA_HUMANC5AR_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04610Complement and coagulation cascades
hsa05150Staphylococcus aureus infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionTASbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0006968cellular defense responseTASbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0050830defense response to Gram-positive bacteriumIEAbiological_process
GO:0021534cell proliferation in hindbrainIEAbiological_process
GO:0006955immune responseTASbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIEAbiological_process
GO:0004944C5a anaphylatoxin receptor activityIEAmolecular_function
GO:0006935chemotaxisTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0002430complement receptor mediated signaling pathwayIEAbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0031100organ regenerationIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0032494response to peptidoglycanIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0007606sensory perception of chemical stimulusTASbiological_process
GO:0030593neutrophil chemotaxisIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0001856complement component C5a bindingIEAmolecular_function


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