Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BRD2_HUMAN
Description:bromodomain containing 2 [Source:HGNC Symbol;Acc:1103]
Location:chrHSCHR6_MHC_MANN p
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S45YEGFEsPTMASPhosphoSitePlus; HPRD; phosphoELM
Y631ALPTGyDSEEEBUD22PhosphoSitePlus
T57PALQLtPANPPPhosphoSitePlus; HPRD; phosphoELM
S611GPSGGsGTKLPHPRD; phosphoELM
S248PSVISsPLLKSPhosphoSitePlus
S50SPTMAsVPALQPhosphoSitePlus; HPRD; phosphoELM
T795SSSSDtSDSDSSPXPhosphoSitePlus
T690EIDFEtLKPSTPhosphoSitePlus
T287KADTTtPTPTAHPRD; phosphoELM
S639EEEEEsRPMSYHPRD; phosphoELM
T6HNKLHPRD
S633PTGYDsEEEEEHPRD; phosphoELM; SysPTM
S785SSDSSsSSSSSSPXPhosphoSitePlus
S301PGSPAsPPGSLPhosphoSitePlus; HPRD; phosphoELM
Y450VFEFRyAKMPDSGT1PhosphoSitePlus
S340QQQHQsSKKGKHPRD
S37RIRKPsLLYEGPhosphoSitePlus
S305ASPPGsLEPKAPhosphoSitePlus; HPRD; phosphoELM
T613SGGSGtKLPKKHPRD; phosphoELM
S775AVSRLsASSSSSPXPhosphoSitePlus
Y40KPSLLyEGFESPhosphoSitePlus
S787DSSSSsSSSSSSPXPhosphoSitePlus
S784SSSDSsSSSSSSPXPhosphoSitePlus
S320PMRREsGRPIKPhosphoSitePlus; HPRD; phosphoELM
S633PTGYDsEEEEEBUD22PhosphoSitePlus; SysPTM
S788SSSSSsSSSSSSPXPhosphoSitePlus
T125PMDMGtIKRRLBromodomainPhosphoSitePlus
T47GFESPtMASVPPhosphoSitePlus; HPRD; phosphoELM
S789SSSSSsSSSSDSPXPhosphoSitePlus
T291TTPTPtAILAPHPRD; phosphoELM
S608SGFGPsGGSGTHPRD
T6MLQNVtPHNKLPhosphoSitePlus
S786SDSSSsSSSSSSPXPhosphoSitePlus
S253SPLLKsLHSAGPhosphoSitePlus
S538QLAALsQGPISSGT1; BUD22; Nop14PhosphoSitePlus
T724KPVGKtKEELAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S298ILAPGsPASPPPhosphoSitePlus; HPRD; phosphoELM; SysPTM

Dephosphorylation site
BRD2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363958W91*Greenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000363964P714LGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000378704R317CCOSMICOvarian Cancer21720365
ENSP00000363958G30EGreenman2007, HPINeoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000363958G30EGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000363958R558GGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000363964R558GGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000382445W91*Greenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000363958E44KBIOMARTBreast Cancer21930507, 21930502
ENSP00000363964E44KBIOMARTBreast Cancer21930507, 21930502
ENSP00000363964W91*Greenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000382445G30EGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000382445P714LGreenman2007Neoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000372588G30EGreenman2007Neoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000382444R558GGreenman2007Gastric Cancer17344846, 18428421
ENSP00000382444W91*Greenman2007Neoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000372588P714LGreenman2007Neoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000372588P714LGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000363958P714LGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000382445P714LGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000382444P714LGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000372588G30EGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000382444G30EGreenman2007Neoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000363958P714LGreenman2007, HPINeoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000363964G30EGreenman2007, HPINeoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000378704E44KBIOMARTBreast Cancer21930507, 21930502
ENSP00000372588W91*Greenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000363964W91*Greenman2007Neoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000378704R528PCOSMICOvarian Cancer21720365
ENSP00000382445G30EGreenman2007Neoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000382445R558GGreenman2007Gastric Cancer17344846, 18428421
ENSP00000363958W91*Greenman2007Neoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000363964P714LGreenman2007, HPINeoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000382444W91*Greenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000372588W91*Greenman2007Neoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000372588R558GGreenman2007Gastric Cancer17344846, 18428421
ENSP00000378704V436LCOSMICSkin Cancer21984974
ENSP00000382444P714LGreenman2007Neoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000378704D160NCOSMICOvarian Cancer21720365
ENSP00000378704R736HCOSMICHead and Neck Cancer21798893
ENSP00000382445W91*Greenman2007Neoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000378704I752LCOSMICOvarian Cancer21720365
ENSP00000363964G30EGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000382444G30EGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421

Differential expressed protein
BRD2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BRD2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANBRD2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
BRD2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0003682chromatin bindingIDAmolecular_function
GO:0006357regulation of transcription from RNA polymerase IIIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016568chromatin modificationIEAbiological_process
GO:0070577histone acetyl-lysine bindingIDAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0006334nucleosome assemblyIMPbiological_process
GO:0007283spermatogenesisTASbiological_process


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