| UniProt/SwissProt ID: | BRD2_HUMAN |
| Description: | bromodomain containing 2 [Source:HGNC Symbol;Acc:1103] |
| Location: | chrHSCHR6_MHC_MANN p |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S45 | YEGFEsPTMAS | PhosphoSitePlus; HPRD; phosphoELM | |
| Y631 | ALPTGyDSEEE | BUD22 | PhosphoSitePlus |
| T57 | PALQLtPANPP | PhosphoSitePlus; HPRD; phosphoELM | |
| S611 | GPSGGsGTKLP | HPRD; phosphoELM | |
| S248 | PSVISsPLLKS | PhosphoSitePlus | |
| S50 | SPTMAsVPALQ | PhosphoSitePlus; HPRD; phosphoELM | |
| T795 | SSSSDtSDSDS | SPX | PhosphoSitePlus |
| T690 | EIDFEtLKPST | PhosphoSitePlus | |
| T287 | KADTTtPTPTA | HPRD; phosphoELM | |
| S639 | EEEEEsRPMSY | HPRD; phosphoELM | |
| T6 | HNKL | HPRD | |
| S633 | PTGYDsEEEEE | HPRD; phosphoELM; SysPTM | |
| S785 | SSDSSsSSSSS | SPX | PhosphoSitePlus |
| S301 | PGSPAsPPGSL | PhosphoSitePlus; HPRD; phosphoELM | |
| Y450 | VFEFRyAKMPD | SGT1 | PhosphoSitePlus |
| S340 | QQQHQsSKKGK | HPRD | |
| S37 | RIRKPsLLYEG | PhosphoSitePlus | |
| S305 | ASPPGsLEPKA | PhosphoSitePlus; HPRD; phosphoELM | |
| T613 | SGGSGtKLPKK | HPRD; phosphoELM | |
| S775 | AVSRLsASSSS | SPX | PhosphoSitePlus |
| Y40 | KPSLLyEGFES | PhosphoSitePlus | |
| S787 | DSSSSsSSSSS | SPX | PhosphoSitePlus |
| S784 | SSSDSsSSSSS | SPX | PhosphoSitePlus |
| S320 | PMRREsGRPIK | PhosphoSitePlus; HPRD; phosphoELM | |
| S633 | PTGYDsEEEEE | BUD22 | PhosphoSitePlus; SysPTM |
| S788 | SSSSSsSSSSS | SPX | PhosphoSitePlus |
| T125 | PMDMGtIKRRL | Bromodomain | PhosphoSitePlus |
| T47 | GFESPtMASVP | PhosphoSitePlus; HPRD; phosphoELM | |
| S789 | SSSSSsSSSSD | SPX | PhosphoSitePlus |
| T291 | TTPTPtAILAP | HPRD; phosphoELM | |
| S608 | SGFGPsGGSGT | HPRD | |
| T6 | MLQNVtPHNKL | PhosphoSitePlus | |
| S786 | SDSSSsSSSSS | SPX | PhosphoSitePlus |
| S253 | SPLLKsLHSAG | PhosphoSitePlus | |
| S538 | QLAALsQGPIS | SGT1; BUD22; Nop14 | PhosphoSitePlus |
| T724 | KPVGKtKEELA | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S298 | ILAPGsPASPP | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Dephosphorylation site |
| BRD2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000363958 | W91* | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 | ENSP00000363964 | P714L | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 | ENSP00000378704 | R317C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363958 | G30E | Greenman2007, HPI | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000363958 | G30E | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 | ENSP00000363958 | R558G | Greenman2007, HPI | Gastric Cancer | 17344846, 18428421 | ENSP00000363964 | R558G | Greenman2007, HPI | Gastric Cancer | 17344846, 18428421 | ENSP00000382445 | W91* | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 | ENSP00000363958 | E44K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000363964 | E44K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000363964 | W91* | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 | ENSP00000382445 | G30E | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 | ENSP00000382445 | P714L | Greenman2007 | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000372588 | G30E | Greenman2007 | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000382444 | R558G | Greenman2007 | Gastric Cancer | 17344846, 18428421 | ENSP00000382444 | W91* | Greenman2007 | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000372588 | P714L | Greenman2007 | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000372588 | P714L | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 | ENSP00000363958 | P714L | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 | ENSP00000382445 | P714L | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 | ENSP00000382444 | P714L | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 | ENSP00000372588 | G30E | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 | ENSP00000382444 | G30E | Greenman2007 | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000363958 | P714L | Greenman2007, HPI | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000363964 | G30E | Greenman2007, HPI | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000378704 | E44K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000372588 | W91* | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 | ENSP00000363964 | W91* | Greenman2007 | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000378704 | R528P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000382445 | G30E | Greenman2007 | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000382445 | R558G | Greenman2007 | Gastric Cancer | 17344846, 18428421 | ENSP00000363958 | W91* | Greenman2007 | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000363964 | P714L | Greenman2007, HPI | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000382444 | W91* | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 | ENSP00000372588 | W91* | Greenman2007 | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000372588 | R558G | Greenman2007 | Gastric Cancer | 17344846, 18428421 | ENSP00000378704 | V436L | COSMIC | Skin Cancer | 21984974 | ENSP00000382444 | P714L | Greenman2007 | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000378704 | D160N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000378704 | R736H | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000382445 | W91* | Greenman2007 | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000378704 | I752L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363964 | G30E | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 | ENSP00000382444 | G30E | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 |
| Differential expressed protein |
| BRD2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| BRD2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AKT1_HUMAN | BRD2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| BRD2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003682 | chromatin binding | IDA | molecular_function |
| GO:0006357 | regulation of transcription from RNA polymerase II | IDA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016568 | chromatin modification | IEA | biological_process |
| GO:0070577 | histone acetyl-lysine binding | IDA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0006334 | nucleosome assembly | IMP | biological_process |
| GO:0007283 | spermatogenesis | TAS | biological_process |