| UniProt/SwissProt ID: | BNC1_HUMAN |
| Description: | basonuclin 1 [Source:HGNC Symbol;Acc:1081] |
| Location: | chr15 q25.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S541 | KSRKSsMPIKI | PKC_alpha | phosphoELM |
| S537 | LPKKKsRKSSM | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S541 | KSRKSsMPIKI | PhosphoSitePlus; HPRD; RegPhos | |
| S541 | KSRKSsMPIKI | PKCa(PKC alpha | RegPhos |
| T965 | VPGCNtMFSSV | PhosphoSitePlus | |
| Dephosphorylation site |
| BNC1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000307041 | N393K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000307041 | R107C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000307041 | S516F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000307041 | G391R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000307041 | R347K | COSMIC | Skin Cancer | 21984974 | ENSP00000307041 | R404H | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| BNC1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| BNC1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | BNC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDKL3_HUMAN | BNC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | BNC1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| BNC1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0050679 | positive regulation of epithelial cell proliferati | IEA | biological_process |
| GO:0042060 | wound healing | IEA | biological_process |
| GO:0006356 | regulation of transcription from RNA polymerase I | IEA | biological_process |
| GO:0006357 | regulation of transcription from RNA polymerase II | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0008284 | positive regulation of cell proliferation | TAS | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0008544 | epidermis development | TAS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | TAS | molecular_function |
| GO:0051276 | chromosome organization | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |