| UniProt/SwissProt ID: | BLK_HUMAN |
| Description: | B lymphoid tyrosine kinase [Source:HGNC Symbol;Acc:1057] |
| Location: | chr8 p23.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S197 | RITFPsLQALV | SH2 | PhosphoSitePlus |
| Y501 | ATERQyELQP_ | PhosphoSitePlus | |
| Y205 | ALVQHySKKGD | SH2 | PhosphoSitePlus |
| Y314 | YIVTEyMARGC | Pkinase_Tyr | PhosphoSitePlus |
| Y389 | IIDSEyTAQEG | Pkinase_Tyr | PhosphoSitePlus |
| Y107 | TGREGyVPSNF | SH3_1 | PhosphoSitePlus |
| Y494 | VLEDFyTATER | PhosphoSitePlus | |
| Y187 | LDEGGyYISPR | SH2 | PhosphoSitePlus |
| Y188 | DEGGYyISPRI | SH2 | PhosphoSitePlus |
| Y309 | TKEPIyIVTEY | Pkinase_Tyr | PhosphoSitePlus |
| Dephosphorylation site |
| BLK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000259089 | P335S | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000259089 | A71T | Greenman2007 | Intestines Cancer | 17344846, 18428421 |
| Differential expressed protein |
| BLK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| BLK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| BLK_HUMAN | KHDR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BLK_HUMAN | BAX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BLK_HUMAN | FCG2B_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| BLK_HUMAN | FCG2A_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| BLK_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0004715 | non-membrane spanning protein tyrosine kinase acti | IDA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0032024 | positive regulation of insulin secretion | IMP | biological_process |
| GO:0050853 | B cell receptor signaling pathway | IDA | biological_process |
| GO:0007243 | intracellular protein kinase cascade | TAS | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |