Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BLK_HUMAN
Description:B lymphoid tyrosine kinase [Source:HGNC Symbol;Acc:1057]
Location:chr8 p23.1
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S197RITFPsLQALVSH2PhosphoSitePlus
Y501ATERQyELQP_PhosphoSitePlus
Y205ALVQHySKKGDSH2PhosphoSitePlus
Y314YIVTEyMARGCPkinase_TyrPhosphoSitePlus
Y389IIDSEyTAQEGPkinase_TyrPhosphoSitePlus
Y107TGREGyVPSNFSH3_1PhosphoSitePlus
Y494VLEDFyTATERPhosphoSitePlus
Y187LDEGGyYISPRSH2PhosphoSitePlus
Y188DEGGYyISPRISH2PhosphoSitePlus
Y309TKEPIyIVTEYPkinase_TyrPhosphoSitePlus

Dephosphorylation site
BLK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000259089P335STCGAOvarian Cancer21720365, 18772890
ENSP00000259089A71TGreenman2007Intestines Cancer17344846, 18428421

Differential expressed protein
BLK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BLK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BLK_HUMANKHDR1_HUMANkinase -> substrateRobert H Newman (2013)
BLK_HUMANBAX_HUMANkinase -> substrateRobert H Newman (2013)
BLK_HUMANFCG2B_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
BLK_HUMANFCG2A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
BLK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0004715non-membrane spanning protein tyrosine kinase actiIDAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0032024positive regulation of insulin secretionIMPbiological_process
GO:0050853B cell receptor signaling pathwayIDAbiological_process
GO:0007243intracellular protein kinase cascadeTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function


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