| UniProt/SwissProt ID: | BICD1_HUMAN |
| Description: | bicaudal D homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:1049] |
| Location: | chr12 p11.21 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S601 | KTPTIsPVITA | BicD | PhosphoSitePlus |
| Y713 | NLKNKyENEKA | BicD | PhosphoSitePlus |
| T605 | ISPVItAPPSS | HPRD | |
| Y300 | KLNGDyRTPTL | BicD | PhosphoSitePlus |
| S601 | KTPTIsPVITA | HPRD | |
| Y448 | KSVENyTDEKA | BicD | PhosphoSitePlus |
| Y406 | EEAHDyEVDIN | BicD | PhosphoSitePlus |
| S569 | ARRGVsSPVET | BicD | PhosphoSitePlus |
| T605 | ISPVItAPPSS | BicD | PhosphoSitePlus |
| S215 | TVLLNsQLEDA | BicD | PhosphoSitePlus |
| Y455 | DEKAKyESKIQ | BicD | PhosphoSitePlus |
| T47 | LEEKLtLKQQY | PhosphoSitePlus | |
| Y52 | TLKQQyDELEA | PhosphoSitePlus | |
| T302 | NGDYRtPTLRK | BicD | PhosphoSitePlus |
| T597 | PSPTKtPTISP | GSK3B | HPRD |
| S585 | PVAKEsTEASK | GSK3B | HPRD |
| S76 | EAFGQsFSIHR | BicD | PhosphoSitePlus |
| Y537 | RVMLDyYRQSR | BicD | PhosphoSitePlus |
| S61 | EAEYDsLKQEL | PhosphoSitePlus | |
| S570 | RRGVSsPVETR | BicD | PhosphoSitePlus |
| T574 | SSPVEtRTSSE | BicD | PhosphoSitePlus |
| T576 | PVETRtSSEPV | BicD | PhosphoSitePlus |
| Y538 | VMLDYyRQSRV | BicD | PhosphoSitePlus |
| S860 | RKRQFsPSLCD | PhosphoSitePlus | |
| T701 | KANKQtAEVAL | BicD | PhosphoSitePlus |
| T844 | SQGPQtPNIRV | PhosphoSitePlus | |
| T304 | DYRTPtLRKGE | BicD | PhosphoSitePlus |
| Dephosphorylation site |
| BICD1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000281474 | R781X | BIOMART | Colorectal Cancer | 21930507, 21930502 | ENSP00000281474 | E513* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000281474 | A564S | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000281474 | R657Q | COSMIC | Central Nervous System Neoplasms | 21163964 | ENSP00000281474 | R781* | COSMIC | Intestines Cancer | 16959974 | ENSP00000281474 | H201Q | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000281474 | R159* | COSMIC | Skin Cancer | 21984974 | ENSP00000281474 | R868C | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| BICD1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| BICD1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GSK3B_HUMAN | BICD1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| BICD1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045298 | tubulin complex | TAS | cellular_component |
| GO:0006810 | transport | IEA | biological_process |
| GO:0005881 | cytoplasmic microtubule | IDA | cellular_component |
| GO:0005856 | cytoskeleton | NAS | cellular_component |
| GO:1900737 | negative regulation of phospholipase C-activating | ISS | biological_process |
| GO:0072393 | microtubule anchoring at microtubule organizing ce | IEA | biological_process |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0045502 | dynein binding | IDA | molecular_function |
| GO:0006396 | RNA processing | TAS | biological_process |
| GO:0008298 | intracellular mRNA localization | NAS | biological_process |
| GO:0048260 | positive regulation of receptor-mediated endocytos | IMP | biological_process |
| GO:1900737 | negative regulation of phospholipase C-activating | IEA | biological_process |
| GO:0005200 | structural constituent of cytoskeleton | TAS | molecular_function |
| GO:1900275 | negative regulation of phospholipase C activity | ISS | biological_process |
| GO:0031410 | cytoplasmic vesicle | IDA | cellular_component |
| GO:0031871 | proteinase activated receptor binding | IEA | molecular_function |
| GO:1900275 | negative regulation of phospholipase C activity | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008093 | cytoskeletal adaptor activity | IDA | molecular_function |
| GO:0034063 | stress granule assembly | ISS | biological_process |
| GO:0034063 | stress granule assembly | IEA | biological_process |
| GO:0072517 | host cell viral assembly compartment | IDA | cellular_component |
| GO:0005802 | trans-Golgi network | IDA | cellular_component |
| GO:0034452 | dynactin binding | IDA | molecular_function |
| GO:0016032 | viral reproduction | IMP | biological_process |
| GO:0005829 | cytosol | IDA | cellular_component |
| GO:0033365 | protein localization to organelle | IDA | biological_process |
| GO:1900276 | regulation of proteinase activated receptor activi | IEA | biological_process |
| GO:0009653 | anatomical structure morphogenesis | TAS | biological_process |
| GO:0031871 | proteinase activated receptor binding | ISS | molecular_function |
| GO:0048471 | perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0072385 | minus-end-directed organelle transport along micro | IMP | biological_process |
| GO:0016020 | membrane | IDA | cellular_component |
| GO:0017137 | Rab GTPase binding | IPI | molecular_function |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:1900276 | regulation of proteinase activated receptor activi | ISS | biological_process |
| GO:0072393 | microtubule anchoring at microtubule organizing ce | ISS | biological_process |