Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BACE2_HUMAN
Description:beta-site APP-cleaving enzyme 2 [Source:HGNC Symbol;Acc:934]
Location:chr21 q22.2
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y93SGRGYyLEMLIAspPhosphoSitePlus
Y295LDCREyNADKAHPRD
Y295LDCREyNADKAAspPhosphoSitePlus
S136DTERSsTYRSKAspPhosphoSitePlus
T137TERSStYRSKGAspPhosphoSitePlus
S368RDENSsRSFRIAspPhosphoSitePlus
S140SSTYRsKGFDVAspPhosphoSitePlus

Dephosphorylation site
BACE2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000332979L362VTCGAOvarian Cancer21720365, 18772890
ENSP00000332979L362VCOSMICOvarian Cancer21720365
ENSP00000332979R139CCOSMICSkin Cancer21984974
ENSP00000332979W154CCOSMICOvarian Cancer21720365
ENSP00000333854T137ABIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000332979W154CTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
BACE2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BACE2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BACE2_HUMANA4_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005768endosomeIEAcellular_component
GO:0006509membrane protein ectodomain proteolysisIDAbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0006508proteolysisNASbiological_process
GO:0016486peptide hormone processingNASbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0016021integral to membraneNAScellular_component
GO:0042985negative regulation of amyloid precursor protein bIMPbiological_process
GO:0004190aspartic-type endopeptidase activityIDAmolecular_function


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