| UniProt/SwissProt ID: | AVEN_HUMAN |
| Description: | apoptosis, caspase activation inhibitor [Source:HGNC Symbol;Acc:13509] |
| Location: | chr15 q14 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y109 | DEQGNySKRKI | PhosphoSitePlus | |
| S94 | PVEDDsDAETY | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S261 | GKDNPsPGPSR | HPRD; phosphoELM | |
| S116 | KRKIVsNWDRY | PhosphoSitePlus | |
| S308 | LPDQTsQDLKS | PhosphoSitePlus; HPRD | |
| S135 | NESGEsQRGTD | PhosphoSitePlus | |
| Y99 | SDAETyGEEND | HPRD; SysPTM | |
| Y121 | SNWDRyQDIEK | PhosphoSitePlus | |
| S273 | SQKPTsPLQSA | PhosphoSitePlus; HPRD | |
| T98 | DSDAEtYGEEN | HPRD; SysPTM | |
| Dephosphorylation site |
| AVEN_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000306822 | S313P | COSMIC | Renal Cancer | |
| Differential expressed protein |
| AVEN_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| AVEN_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AKT1_HUMAN | AVEN_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| AVEN_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016020 | membrane | IDA | cellular_component |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0005622 | intracellular | IDA | cellular_component |
| GO:0012505 | endomembrane system | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0043066 | negative regulation of apoptotic process | IDA | biological_process |