Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ASIC3_HUMAN
Description:acid-sensing (proton-gated) ion channel 3 [Source:HGNC Symbol;Acc:101]
Location:chr7 q36.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y429EQKKAyEMSELASCPhosphoSitePlus
S493QEGLGsHRTQVHPRD
Y375CASTRyAKELSHPRD
S5PEEAHPRD
S478WNRQHsQRHSSHPRD
S491LTSHPsLCRHQHPRD
S39GPGSLsLRRGMHPRD
S5PEEACSNK2A1HPRD

Dephosphorylation site
ASIC3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000344838P259STCGAOvarian Cancer21720365, 18772890
ENSP00000344838*532RCOSMICBreast Cancer20668451
ENSP00000350600P277SBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000344838P277SCOSMICCentral Nervous System Neoplasms18772396
ENSP00000344838P259SCOSMICOvarian Cancer21720365
ENSP00000344838S156FCOSMICSkin Cancer21984974

Differential expressed protein
ASIC3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ASIC3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANASIC3_HUMANkinase -> substrateRegPhos
CSK21_HUMANASIC3_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
ASIC3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0001101response to acidIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0035725sodium ion transmembrane transportTASbiological_process
GO:0009408response to heatIEAbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0034220ion transmembrane transportIEAbiological_process
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0042930enterobactin transportIEAbiological_process
GO:0007600sensory perceptionTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0050907detection of chemical stimulus involved in sensoryIEAbiological_process
GO:0015280ligand-gated sodium channel activityIEAmolecular_function
GO:0050961detection of temperature stimulus involved in sensIEAbiological_process
GO:0042931enterobactin transporter activityIEAmolecular_function
GO:0050974detection of mechanical stimulus involved in sensoIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0050965detection of temperature stimulus involved in sensIEAbiological_process
GO:0050966detection of mechanical stimulus involved in sensoIEAbiological_process
GO:0006812cation transportIEAbiological_process
GO:0006810transportTASbiological_process
GO:0005272sodium channel activityTASmolecular_function
GO:0030165PDZ domain bindingIEAmolecular_function
GO:0050968detection of chemical stimulus involved in sensoryIEAbiological_process
GO:0006814sodium ion transportIEAbiological_process
GO:0005261cation channel activityTASmolecular_function


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