Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ASIC1_HUMAN
Description:acid-sensing (proton-gated) ion channel 1 [Source:HGNC Symbol;Acc:100]
Location:chr12 q13.12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S479EAKRSsADKGVPKA_groupphosphoELM
S479EAKRSsADKGVPRKACAHPRD
S525EAKRSsADKGVPRKACAHPRD

Dephosphorylation site
ASIC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000400228*529WCOSMICMelanoma21499247
ENSP00000400228*529WCOSMICMelanoma21499247
ENSP00000228468R201QCOSMICSkin Cancer21984974
ENSP00000228468S251CCOSMICOvarian Cancer21720365
ENSP00000400228S251CTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
ASIC1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ASIC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANASIC1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
ASIC1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionTASbiological_process
GO:0005272sodium channel activityIEAmolecular_function
GO:0042391regulation of membrane potentialIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016020membraneIEAcellular_component
GO:0005261cation channel activityIEAmolecular_function
GO:0046929negative regulation of neurotransmitter secretionIEAbiological_process
GO:0015280ligand-gated sodium channel activityNASmolecular_function
GO:0005216ion channel activityIEAmolecular_function
GO:0001101response to acidIEAbiological_process
GO:0006814sodium ion transportNASbiological_process
GO:0045202synapseIEAcellular_component
GO:0006812cation transportIEAbiological_process
GO:0022839ion gated channel activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0006810transportTASbiological_process
GO:0034220ion transmembrane transportIEAbiological_process
GO:0070588calcium ion transmembrane transportIEAbiological_process
GO:0008306associative learningIEAbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0009268response to pHTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0007613memoryIEAbiological_process


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