Phosphorylation

Protein information

UniProt/SwissProt ID:	ASIC1_HUMAN
Description:	acid-sensing (proton-gated) ion channel 1 [Source:HGNC Symbol;Acc:100]
Location:	chr12 q13.12
Node attribute:	substrate

Position	PhosphoPeptide	Catalytic kinase	Source
S479	EAKRSsADKGV	PKA_group	phosphoELM
S479	EAKRSsADKGV	PRKACA	HPRD
S525	EAKRSsADKGV	PRKACA	HPRD

ASIC1_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000400228	*529W	COSMIC	Melanoma	21499247
ENSP00000400228	*529W	COSMIC	Melanoma	21499247
ENSP00000228468	R201Q	COSMIC	Skin Cancer	21984974
ENSP00000228468	S251C	COSMIC	Ovarian Cancer	21720365
ENSP00000400228	S251C	TCGA	Ovarian Cancer	21720365, 18772890

ASIC1_HUMAN is not differential expressed protein.

ASIC1_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
KPCA_HUMAN	ASIC1_HUMAN	kinase -> substrate	HPRD

KEGG Pathway

ASIC1_HUMAN is not in KEGG pathway.

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0007165	signal transduction	TAS	biological_process
GO:0005272	sodium channel activity	IEA	molecular_function
GO:0042391	regulation of membrane potential	IEA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0016020	membrane	IEA	cellular_component
GO:0005261	cation channel activity	IEA	molecular_function
GO:0046929	negative regulation of neurotransmitter secretion	IEA	biological_process
GO:0015280	ligand-gated sodium channel activity	NAS	molecular_function
GO:0005216	ion channel activity	IEA	molecular_function
GO:0001101	response to acid	IEA	biological_process
GO:0006814	sodium ion transport	NAS	biological_process
GO:0045202	synapse	IEA	cellular_component
GO:0006812	cation transport	IEA	biological_process
GO:0022839	ion gated channel activity	IEA	molecular_function
GO:0005515	protein binding	IEA	molecular_function
GO:0006810	transport	TAS	biological_process
GO:0034220	ion transmembrane transport	IEA	biological_process
GO:0070588	calcium ion transmembrane transport	IEA	biological_process
GO:0008306	associative learning	IEA	biological_process
GO:0005887	integral to plasma membrane	IEA	cellular_component
GO:0009268	response to pH	TAS	biological_process
GO:0016021	integral to membrane	IEA	cellular_component
GO:0007613	memory	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network