| UniProt/SwissProt ID: | ASCC3_HUMAN |
| Description: | activating signal cointegrator 1 complex subunit 3 [Source:HGNC Symbol;Acc:18697] |
| Location: | chr6 q16.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S2195 | TKVSDsLTDLA | PhosphoSitePlus; HPRD | |
| T592 | KWDVVtRKSVG | DEAD | PhosphoSitePlus |
| T1915 | DTDTKtVLDQA | HPRD | |
| S1746 | GGTITsKQDAL | PhosphoSitePlus | |
| S1490 | RIVGLsTALAN | DEAD | PhosphoSitePlus |
| S595 | VVTRKsVGDVA | HPRD | |
| S640 | VESTQsMIRIL | DEAD | PhosphoSitePlus |
| T1915 | DTDTKtVLDQA | Sec63 | PhosphoSitePlus |
| T1480 | FISSHtEKPVR | DEAD | PhosphoSitePlus |
| T973 | RFEERtGYFSS | PhosphoSitePlus | |
| S1553 | AIRSHsPAKPV | PhosphoSitePlus; HPRD | |
| Y1909 | LPCPDyDTDTK | Sec63 | PhosphoSitePlus |
| Y975 | EERTGyFSSTD | PhosphoSitePlus | |
| T209 | LQEACtPELKP | PhosphoSitePlus | |
| S170 | KNLAFsFDMHD | PhosphoSitePlus | |
| T584 | QMLVTtPEKWD | DEAD | PhosphoSitePlus |
| S1551 | FQAIRsHSPAK | PhosphoSitePlus; HPRD | |
| S637 | LRQVEsTQSMI | DEAD | PhosphoSitePlus |
| S1131 | PLRQFsILPPH | Sec63 | PhosphoSitePlus |
| S1563 | VLIFVsSRRQT | PhosphoSitePlus; HPRD | |
| T578 | SEILRtQMLVT | DEAD | PhosphoSitePlus |
| T1745 | AGGTItSKQDA | PhosphoSitePlus | |
| T565 | IVKELtGDMQL | HPRD | |
| Dephosphorylation site |
| ASCC3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000358159 | L1110Q | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| ASCC3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ASCC3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TGFR2_HUMAN | ASCC3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ASCC3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0032508 | DNA duplex unwinding | IDA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0017111 | nucleoside-triphosphatase activity | IEA | molecular_function |
| GO:0043140 | ATP-dependent 3'-5' DNA helicase activity | IDA | molecular_function |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0006307 | DNA dealkylation involved in DNA repair | IDA | biological_process |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0004386 | helicase activity | IEA | molecular_function |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005622 | intracellular | IDA | cellular_component |
| GO:0008283 | cell proliferation | IMP | biological_process |
| GO:0016787 | hydrolase activity | IEA | molecular_function |